Senior Scientist Capsid Engineering
Senior Scientist Capsid Engineering
Employer Active
Job Alert
You will be updated with latest job alerts via email
Share
Job Alert
You will be updated with latest job alerts via email
$ 103400 - 192000
1 Vacancy
Job Description
At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.
The Position
At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.
A healthier future. Its what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. Thats what makes us Roche.
The Senior Scientist Capsid Engineering is a key member of the Discovery Research Team and participates in the development of Sparks gene delivery platforms. You will be critical for the development of novel AAV capsids with enhanced properties in particular the ability to transduce specific cell types. The discovery of such capsids will greatly facilitate the translation fromin vitrothroughin vivoproof of concept and ultimately the clinic.
The Opportunity:
Ideate experimental strategies to engineer novel capsids with enhanced properties for clinical translation.
Developing and implementing highthroughput capsid library screening strategies to discover improved variants.
Supporting approaches that allow the isolation of AAV capsid variants that transduce specific cell types in both rodents and NHPs.
Actively collaborate with the NGS and machine learning groups to further enhance the power of using directed evolution to isolate AAVs with tailored properties.
Collaborating with other Discovery and Gene Therapy scientists to design and conductin vitrostudies in preclinical animal models of genetic diseases.
Supporting joint programs and collaborations with external parties.
Writing study reports manuscripts and present results at appropriate scientific meetings.
Who You Are:
PhD in a biological discipline and 35 years of related experience.
Handson research experience with high complexity library preparations.
Familiarity with NGS and bioinformatics is required.
Experience in general and advanced lab techniques such as plasmid design and construction molecular cloning qPCR cell culture ELISA platebased luciferase and/or enzymatic activity assays SDSPAGE/Western blotting etc. is required.
Experience with AAV gene therapy is required.
Travel may be required but infrequently and for short periods of time.
Preferred Qualifications:
Experience with studies in laboratory animal models is preferred.
Strong analytical skills and problemsolving capabilities.
Familiar with computer software commonly used in bio/pharma industries.
Strong publication record is a plus.
Experience managing external collaborations is a plus.
The expected salary range for this position based on the primary location of Philadelphia is $103400 to $ pay will be determined based on experience qualifications geographic location and other jobrelated factors permitted by law.
This position also qualifies for the benefits detailed at the link provided below.
Who we are
A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver lifechanging healthcare solutions that make a global impact.
Lets build a healthier future together.
Roche is an equal opportunity employer. It is our policy and practice to employ promote and otherwise treat any and all employees and applicants on the basis of merit qualifications and competence. The companys policy prohibits unlawful discrimination including but not limited to discrimination on the basis of Protected Veteran status individuals with disabilities status and consistent with all federal state or local laws.
If you have a disability and need an accommodation in relation to the online application process please contact us by completing this form Accommodations for Applicants.
Required Experience:
Senior IC
Employment Type
Full-Time
