Associate Scientist Research
Associate Scientist Research
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Job Description
Overview
Associate Scientist will work on developing methods to optimize the antitumor activity of tumorinfiltrating lymphocytes (TIL) for therapeutic applications. Such methods include the use of gene editing gene augmentation and other ex vivo manipulations of TILs during the expansion process aiming at improving the function trafficking and persistence of TILs. The position requires prior experience working in a research laboratory. The ideal candidate will have experience with cellular assays ddPCR qPCR other molecular biology techniques knowledge of gene therapy and gene editing and skills in viral vector production and analysis. This position requires an individual to be very motivated and bring impactful work to the team to help move new TIL approaches into the clinic.
Essential Functions and Responsibilities
- Work as part of a research and development group to support ongoing projects in the lab.
- Design and execute experimental plans and protocols consistently.
- Produce and characterize viral vectors. Perform and analyze vector transduction and transgene expression.
- Deliver gene editing components using various approaches and assess editing efficiencies.
- Develop assays to evaluate functions of genetically modified TILs.
- Analyze and interpret experimental results. Make detailed observations and record them in a timely and relevant fashion.
- Capability for troubleshooting technical issues and presenting ideas to the team.
- Investigate and develop new methods and technologies necessary for project advancement.
- Write corresponding SOPs.
- Contribute to scientific publications and regulatory document writing.
- Help identify patentable inventions.
- Must adhere to Iovance Biotherapeutics core values policies procedures and business ethics.
- Comply with Safety SOPs SDS sheets and laboratory procedures per company policy and OSHA regulations.
- Perform all other related duties as assigned
Required Education Skills and Knowledge
- Masters Degree (MS) in Cellular Biology Molecular Biology Immunology or related discipline with 3 years of relevant work experience (industrial experience preferred).
- Bachelors degree (BA/BS) in Cellular Biology Molecular Biology Immunology or related discipline with 5 years of relevant working experience (industrial experience preferred).
- High motivation and flexibility to adapt to new situations and be part of a dynamic and growing team.
- Extensive experience in viral vector production characterization and analysis is required.
- Skills in molecular biology ddPCR or qPCR gene editing flow cytometry tissue culture using primary and established cell lines and immunological assays are preferred.
- Knowledge of gene therapy gene editing and cell therapy is preferred.
- Ability to independently carry out all lab experiments analyze and interpret experimental results make detailed observations and record them in a timely and relevant fashion.
- Ability to organize presentation and discussion results and develop new methods and technologies necessary for project advancement.
- Excellent recordkeeping and organization skills are needed.
- Must be able to communicate (verbal and written) effectively.
- Excellent collaborative style.
Preferred Education Skills and Knowledge
- Ph.D. in Cellular Biology Molecular Biology Immunology or related discipline with 02 years of postdoc or industry experience
The physical demands described here represent those that an employee must meet to perform the essential functions of this job successfully. Reasonable accommodations may be made upon request to enable individuals to perform essential functions. Please contact Human Resources to request an accommodation.
Physical Demands and Activities Required
- Must be able to move to and from the office to the lab located on separate floors and move about the office and lab as needed.
- Must be able to remain in a stationary position standing or sitting for prolonged periods of time.
- Must be able to grasp with both hands perform repetitious actions such as pinch with thumb and forefinger turn with hand/ arm and reach above shoulder height.
- Must be able to use several types of laboratory equipment and pipettes for extended periods.
- Must be able to work on a tablet or computer typing for 50 of a typical working day.
- Must be able to move and lift 20 pounds multiple times daily.
- Must be able to use near vision to view samples at close range.
- Wear proper personal protective equipment when in a laboratory setting i.e. safety glasses lab coats and closedtoed shoes.
Mental: Clear and conceptual thinking ability; excellent judgment troubleshooting problemsolving analysis and discretion; ability to handle workrelated stress; ability to handle multiple priorities simultaneously; and ability to meet deadlines
Work Environment
This position will work in both an office and a laboratory setting. When in the lab there may be a risk of exposure to hazardous or biological waste within the environment through receipt transport storage preparation dispensing administration cleaning and/or disposal of contaminated areas and waste.
The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions duties or local variances. Management retains the discretion to add or to change the duties of the position at any time.
Iovance is committed to cultivating and offering a diverse and inclusive work environment. As an equalopportunity employer our employees and applicants will be considered without regard to an individuals race color religion sex pregnancy national origin age physical and mental disability marital status sexual orientation gender identity gender expression genetic information military and veteran status and any other characteristic protected by applicable law. If you need assistance or accommodation to apply to one of our opportunities please contact .
By voluntarily providing information and clicking Submit Application you explicitly consent to the collection and use of your personal information for the purposes described above and in our Candidate Privacy Notice.
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Required Experience:
Senior IC
Employment Type
Full-Time
