Research Assistant 100 Investigating the impact of 2D Materials pesticides and chemicals on the intestinal and skin barrier using in vitro co-culture models
Research Assistant 100 Investigating the impact of 2D Materials pesticides and chemicals on the intestinal and skin barrier using in vitro co-culture models
Posted on :
15-04-2025
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1 Vacancy
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Monthly Salary
Not Disclosed
Salary Not Disclosed
Vacancy
1 Vacancy
Posted on :
15-04-2025
Job Description
Materials science and technology are our passion. With our cuttingedge research Empas around 1100 employees make essential contributions to the wellbeing of society for a future worth living. Empa is a research institution of the ETH Domain.
The Nanomaterials in Health Lab enables particlebased solutions for diagnostics and therapeutics driven by clinical needs. We are active in characterizing understanding and steering the interaction of particulate materials with human cells or tissues and provide expertise in the interdisciplinary field of particulate materials safety and applications for industry or authorities.
Your tasks
Understanding the effects of 2D materials pesticides and chemicals on biological barriers is crucial for assessing their potential risks to human health. The intestinal and skin barriers serve as primary defense mechanisms and their disruption can lead to systemic exposure toxicity or inflammatory responses. This project aims to evaluate barrier integrity cell viability and molecular responses using advanced in vitro biobarrier models. It is part of the EU CHIASMA project aiming to develop and demonstrate a comprehensive set of New Approach Methodologies (NAMs) and integrate them into a userfriendly reliable and robust framework for human and environmental safety evaluation in a regulatory context.
Your key tasks will include:
- Establishing and maintaining intestinal and skin in vitro barrier models in the cell culture lab
- Assessing barrier integrity using NaFlu (sodium fluorescein) size exclusion assays
- Evaluating cell viability through MTT and LDH assays to determine cytotoxic effects and establish doseresponse curves
- Quantifying relevant protein expression via immunostaining techniques to assess molecular changes upon exposure
- Analyzing the effects of different chemicals and materials on barrier functionality viability and inflammatory responses
- Documenting analyzing and interpreting experimental results
Your profile
- MSc. degree in biology toxicology life sciences or a related field
- High motivation to work in an interdisciplinary project
- Experience with cell culture work
- Expertise in microscopy and immunochemical stainings
- Skills in data analysis and interpretation
- Proficient in both written and spoken English
Our offer
- A highly stimulating research environment in the Empa laboratories in
- Access to stateoftheart infractructure and equipment
- Opportunity for close collaborations with experts from different fields (engineers chemists clinicians)
- Support for personal development
The project will be carried out at Empa under the supervision of Dr. Tina BuerkiThurnherr. The position is available starting from September 2025 or upon agreement for an initial duration of 1 year.
We look forward to receiving your complete online application including a letter of motivation CV certificates diplomas and contact details of two reference persons. Please submit these exclusively via our job portal. Applications by email and by post will not be considered.
SarahStdli Bereichspersonalleiterin / HR Partner
Employment Type
Full-Time
Key Skills
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