Principal Scientist Shuttled Oligonucleotide Therapeutics
Principal Scientist Shuttled Oligonucleotide Therapeutics
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Job Description
Manifold Bio is a dynamic biotech company building a pipeline of targeted biologics using a novel in vivocentric discovery approach. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other highthroughput protein engineering approaches with computational design to create antibodylike and other biologics. Our worldclass team of protein engineers biologists and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.
Position
Manifold Bio is seeking an experienced Principal Scientist to lead our shuttled oligonucleotide therapeutics programs. In this role you will serve as a dedicated scientific leader for our oligo programs accelerating progress on key milestones while leveraging our shuttle technology for targeting peripherally administered oligonucleotide therapeutics to specific tissues and cells. You will define the strategy for expanding our oligo capabilities and organize crossfunctional teams and explore external collaborations to design novel ASOs siRNAs and linkers building an efficient screening and production system that leverages our ability to do multiplexed screening in vivo. As a scientific leader you will bring strong expertise in oligo medicines to partner conversations and accelerate the discovery of oligo therapeutics by establishing efficient techniques and assays.
Responsibilities
- Define strategy and lead discovery and development of shuttledoligonucleotide based therapeutics
- Combine handson at the bench planning and coordination among internal and external teams to rapidly advance programs
- Provide subject matter expertise to crossfunctional drug discovery project teams collaborating closely with protein engineers in vitro biologists bioconjugation scientists and in vivo biologists to discover and progress shuttled oligobased therapeutics
- Build an oligo screening and production system that supports the efficient discovery and optimization of novel ASOs siRNAs and linkers
- Build and execute techniques and assays that accelerate oligo therapeutic discovery
- Select and manage external vendors necessary to support oligo discovery and development efforts
- Provide scientific leadership for internal and partnered oligo drug development programs
- Provide expert scientific and strategic input into the design of proofofconcept studies demonstrating successful CNS target knockdown using shuttled oligos
- Clearly communicate scientific progress and challenges to team members leadership and collaborators
- Closely track advances in the field and provide strategic direction for continued development and expansion of Manifolds shuttled oligo discovery efforts.
Required Qualifications
- PhD in a relevant field (nucleic acid chemistry/biology biochemistry biophysics molecular biology or related discipline)
- Minimum of 6 years postPhD experience including experience in biotech/pharma drug discovery and development
- Strong background in oligonucleotide chemistry including backbone and base modifications to improve potency and other desired properties
- Experience building and/or optimizing platforms for oligo design synthesis and screening
- Handson experience with multiple oligonucleotide modalities (ASOs siRNAs aptamers mRNA) and different backbone chemistries/modifications
- Experience progressing oligonucleotide therapies through nonclinical/early clinical development
- Knowledge of proven and emerging technologies for delivering oligo medicines to cellular targets (LNPs passive or active targeting moieties etc.
- Understanding of DMPK toxicology and developability considerations specific to oligos
- Excellent written and verbal communication skills
Preferred Qualifications
- Experience designing linkers and/or active delivery mechanisms for tissuetargeted nucleotide therapeutics
- Experience in the design and interpretation of cellbased or in vivo measurement of oligonucleotide efficacy
- Experience with in vivo knockdown studies
- Demonstrated leadership of small scientific teams
- Experience leading matrixed project teams through discovery and/or development efforts
- Demonstrated ability to mentor junior scientists
- Strong presentation skills and design sensibility
This Role Might Be Perfect For You If:
You are curious and passionate about science and drug discovery and want to work with a fastmoving team that values scientific boldness and innovation. This role requires deep technical expertise combined with a willingness to work thoughtfully and quickly to solve scientific challenges in a collaborative manner. You value an experimental approach and generating highquality data to empower rapid datadriven decisionmaking with a commitment to meet or beat critical deadlines. You should be a team player who is also proactive and resourceful.
If youre excited to use unique protein technologies to shape an innovative drug development strategy build meaningful industry partnerships and contribute directly to our mission of advancing breakthrough treatments please apply!
We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures genders and backgrounds.
Required Experience:
Staff IC
Employment Type
Full Time
