Associate Scientist - Oncology
Associate Scientist - Oncology
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$ 109650 - 141900
1 Vacancy
Job Description
At Gilead were creating a healthier world for all people. For more than 35 years weve tackled diseases such as HIV viral hepatitis COVID19 and cancer working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the worlds biggest health challenges and our mission requires collaboration determination and a relentless drive to make a difference.
Every member of Gileads team plays a critical role in the discovery and development of lifechanging scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions and were looking for the next wave of passionate and ambitious people ready to make a direct impact.
We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future you are the key driver in evolving our culture and creating an environment where every employee feels included developed and empowered to fulfil their aspirations. Join Gilead and help create possible together.
Job Description
The Oncology department at Gilead Sciences is seeking an experienced and motivated Associate Scientist with exceptional technical skills to support research programs focused on the discovery and development of novel therapies that mobilize the immune response against cancer. The successful candidate will be instrumental in leading cell engineering efforts including generation of genetically modified cell lines and conducting experiments and help develop novel assays to test therapeutic hypotheses and advance immune engager therapeutic candidates to selectively target tumors. Candidate will also develop novel assays and conduct experiments to test therapeutic hypotheses and advance immune engager therapeutic candidates to selectively target tumors.
Our highly diverse collaborative and interdisciplinary research teams utilize stateoftheart technologies and innovative methodologies to advance novel immunooncology therapies into the clinic. The position has ample opportunities for career growth through acquisition of new skills experiences and professional relationshipsin an inclusive fastpaced and resourcerich environment. The successful candidate will contribute to therapeutic candidate characterization in immune cellmediated killing assays new admixed immune cells / cancer cells assay development mechanism of action studies and flow cytometrybased immune profiling/phenotyping studies in vitro and from dissociated mouse tumor samples.
Key Responsibilities
Primary responsibility to support target validation efforts through characterization and generation of cellular models including genetically modified cell lines (CRISPR knockout) and overexpressing cell lines with contributions to multiple projects
Explore mechanism of action of immune engager molecules by characterizing mouse surrogate molecules developing genetically engineered mouse cancer cell lines
Help develop novel complex cell biology assays to model tumor biology more physiologically than traditional cell culture systems (organoid sequential killing assays)
Prepare and present findings to the team and at departmentwide meetings
Contribute figures to research reports manuscripts INDs and patent filings
Knowledge Experience and Skills
Industry research experience preferred (BS 4 years OR MS 2 years) in cancer immunology or related field with a record of achievements (publications)
Proficiency with cell culture methods
Experience with gene knockdown (RNAi) knockout (CRISPR/Cas9 and overexpression techniques (transfection viral transduction)
Experience with RNA and protein quantification techniques (RTqPCR Nanostring MSD/ELISA western)
Basic flow cytometry skills proficiency with multiparametric Flow Cytometry experiments preferred
Experience in running and developing cellbased assays (ADCC or T cellmediated killing assays Jurkat reporter assays etc)
Independently execute and analyze studies
Great attention to detail with excellent organizational and record keeping skills
Strong motivation independence and ability to think critically and act creatively to resolve problems
Excellent communication and interpersonal skills and ability to integrate into a highpaced multidisciplinary environment
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For Current Gilead Employees and Contractors:
Please apply via the Internal Career Opportunities portal in Workday.
Required Experience:
IC
Employment Type
Full-Time
