Senior Scientist - Structural Biology
Senior Scientist - Structural Biology
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Job Description
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ScientificJob Description
Join Amgens Mission of Serving Patients
At Amgen if you feel like youre part of something bigger its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.
Since 1980 weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology Inflammation General Medicine and Rare Disease we reach millions of patients each year. As a member of the Amgen team youll help make a lasting impact on the lives of patients as we research manufacture and deliver innovative medicines to help people live longer fuller happier lives.
Our awardwinning culture is collaborative innovative and science based. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Senior Scientist Structural Biology
What you will do
Lets do this. Lets change the world. In this vital role you will join the Structural Biology Department at our Research site in Burnaby British Columbia Canada. The Structural Biology laboratory provides comprehensive molecular insights and structurebased design for drugtarget assessment mechanism of action proteinprotein and proteinligand interactions as well as protein engineering to facilitate drug discovery across various therapeutic areas.
- Structure determination of target molecules in our large molecule and small molecule programs primarily using cryoelectron microscopy (cryoEM). Experience in Xray crystallography is a plus.
- Work closely with computational biologists and protein biochemists in the protein biochemistry group and protein design group.
- Collaborate with teams across various functions in the Therapeutic Discovery Research organization including Biologic Discovery Discovery Protein Science and Digital Biologics Discovery to develop strategies toward therapeutic protein deimmunization.
- Participate deeply in the structural biology projects related to immunogenicity.
What we expect of you
We are all different yet we all use our unique contributions to serve patients. The professional we seek is a scientist with these qualifications.
Basic Qualifications:
- Ph.D. with a deep understanding of structural biology and general biochemistry.
- Significant postdoctoral research experience in large macromolecular complex structure determination. Knowledge of stateoftheart protein structural biology techniques including all aspects of construct design expression purification characterization structure determination and analysis.
- Expertise on cryoEM single particle analysis to determine atomic resolution structures.
- Excellent presentation skills (written and oral) for effective teambased communication of results.
- Ability to work independently and effectively within timelines and to collaborate in a multidisciplinary environment.
- Skills in managing multiple projects and capability to prioritize.
Preferred Qualifications:
- Experience with immune biology and molecular basis of immunogenicity.
- Experience with innovative method development in protein biochemistry including protein rigidification protein folding and TEM grid substrate derivatization etc.
- Experience with other protein biochemical and/or biophysical characterization of protein complexes.
What you can expect of us
As we work to develop treatments that take care of others we also work to care for your professional and personal growth and wellbeing. From our competitive benefits to our collaborative culture well support your journey every step of the way.
The annual base salary range for this opportunity in Canada is $96000 $130000 CAD.
In addition to the base salary Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.
Apply now
for a career that defies imagination
Objects in your future are closer than they appear. Join us.
careers.amgen
As an organization dedicated to improving the quality of life for people around the world Amgen fosters an inclusive environment of diverse ethical committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race color religion sex sexual orientation gender identity national origin protected veteran status disability status or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. Please contact us to request accommodation.
.Required Experience:
Senior IC
Employment Type
Full-Time
