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The Position

A healthier future. Its what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. Thats what makes us Roche.

The Position

The Organoid Gene Editing Group led at the Institute of Human Biology (IHB) at Roche in Basel Switzerland is hosting an internship position for a researcher to study cell fate decisions in homeostasis and early carcinogenesis focused on the gastrointestinal epithelium. Your research will involve cuttingedge 3D organoid models and engineered systems thereof combined with highcontent imaging and genomic technologies to interrogate cell fate decisions.

This study may yield new insights into the factors governing cell maturation that could be used to direct lineage specification in in vitro models for specific use cases. Moreover it may provide therapeutic angles to treat gastrointestinal diseases such as metabolic disease for instance by targeting intestinal cell types producing antiappetite hormones.

Your Profile

You are currently enrolled in a university M.Sc. program in relevant subjects such as molecular biology biotechnology bioengineering chemical biology or related fields or you have completed your degree in the respective subjects within the past 12 months.

• You have experience in primary cell culture. Prior experience with the culture of complex human model systems such as organoids is highly desirable.

• Prior experience with CRISPRbased genetic engineering flow cytometry imaging ELISAs and/or sequencing is highly desirable.

• You are fluent in English and highly curious about science and are able to derive novel approaches and ideas from published literature.

• You want to work in a highly collaborative environment where scientific exchange is highly valued.

• You are able to plan and perform experiments independently including their thorough interpretation and efficient documentation.

Your impact

• Perform computational analyses of single cell genomic and genetic perturbation data

• Execute genetic perturbation experiments to identify gene regulatory networks setting intestinal cell fates

• Interpret experimental data and report these in presentations and a written report to colleagues

Your application

Your complete application should include the following documents:

• An uptodate CV and a Motivation Letter

• A certificate of enrollment (if you are currently studying)

• For NonEU/EFTA citizens: Due to regulations you must provide a letter from your university stating that an internship is mandatory for your studies and specifying the required length of the internship. Please upload this letter along with your enrollment certificate CV and motivation letter.

Employment: 100

Start date: As soon as possible; flexible

Duration: 912 months

Location: Basel Switzerland

If you are proud of contributing and feel you have the dedication to teamwork and innovation that we are seeking then Roche is the organization for you. Every role at Roche plays a part in making a difference to patients lives.

If you want to work in a passionate team make your mark & improve lives apply now.

Who we are

A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver lifechanging healthcare solutions that make a global impact.

Lets build a healthier future together.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10700 employees from over 100 countries come together at our Basel/Kaiseraugst site which is one of Roches largest sites. Read more.

Besides extensive development and training opportunities we offer flexible working options 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as childcare facilities medical services restaurants and cafeterias as well as various employee events.