Principal Scientist - Safety Pharmacology
Principal Scientist - Safety Pharmacology
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$ 173068 - 173068
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Job Description
Career Category
ResearchJob Description
Join Amgens Mission of Serving Patients
At Amgen if you feel like youre part of something bigger its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.
Since 1980 weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology Inflammation General Medicine and Rare Disease we reach millions of patients each year. As a member of the Amgen team youll help make a lasting impact on the lives of patients as we research manufacture and deliver innovative medicines to help people live longer fuller happier lives.
Our awardwinning culture is collaborative innovative and science based. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Principal Scientist Safety Pharmacology
What you will do
Lets do this. Lets change the world. The Translational Safety and Bioanalytical Sciences (TS&BA) function at Amgen is seeking candidates for the position of Principal Scientist to join our Safety Pharmacology Sciences (SP Sci) team based in Thousand Oak CA. The SP Sci team supports the Amgen portfolio from target identification through clinical development with an emphasis on developing translational safety strategies to support project teams and various drug modalities. The Principal Scientist will be part of an expert team dedicated to the development of small molecules oligonucleotides and protein therapeutics in close collaboration with toxicologists pathologists and scientists within the organization. In this vital role you will design and perform in vitro assays for various projects and present the work to crossfunctional teams. Additionally multiple opportunities exist for the new hire to grow their career by leveraging their subject matter expertise to innovate (i.e. new model development) collaborate with other members of the SP Sci team (i.e. present key finding at internal/external meetings) and engage with drug discovery project teams (i.e. advance new molecules into clinical development).
Responsibilities:
- Serve as an in vitro and ex vivo electrophysiologist supporting investigative activities by employing electrophysiology techniques (conducted internally or outsourced) to assess the impact of test compounds on ion channels cells and isolated tissues such as the isolated perfused heart.
- Provide subject matter expertise in developing fitforpurpose translational safety strategies to address new challenges within the Amgen drug pipeline.
- The successful candidate will have an indepth understanding of ion channel biophysics and pharmacology (especially cardiac) with proven ability to apply this knowledge in the development and validation of assays related to ion channel and cardiac function.
- The candidate will hold subject matter expertise in a particular area which could include use of hiPSCderived cardiomyocytes for compound screening dissociated primary cells or heterologous mammalian cell expression systems and techniques such as patch clamp multielectrode array (MEA) recording or calcium imaging.
- Experience with artificial intelligence machine learning and/or programming would be advantageous.
- The candidate should have a resultsfocused attitude with a track record of independent critical thinking and scientific achievement in the area of electrophysiology
- The candidate should have strong verbal and written communication skills be highly motivated creative and collaborative with the ability to work in a team environment.
What we expect of you
We are all different yet we all use our unique contributions to serve patients. The dynamic professional we seek is a subject matter expert with these qualifications.
Basic Qualifications:
Doctorate degree PhD OR PharmD OR MD and relevant postdoc where applicable in a relevant scientific discipline (e.g. physiology or pharmacology) and 2 years of electrophysiology experience.
Or
Masters degree and 5 years of electrophysiology experience.
Or
Bachelors degree and 7 years of electrophysiology experience.
Preferred Qualifications:
Pharmaceutical industry electrophysiology experience.
What you can expect of us
As we work to develop treatments that take care of others we also work to care for your professional and personal growth and wellbeing. From our competitive benefits to our collaborative culture well support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills experience and qualifications.
In addition to the base salary Amgen offers a Total Rewards Plan based on eligibility comprising of health and welfare plans for staff and eligible dependents financial plans with opportunities to save towards retirement or other goals work/life balance and career development opportunities that may include:
- A comprehensive employee benefits package including a Retirement and Savings Plan with generous company contributions group medical dental and vision coverage life and disability insurance and flexible spending accounts
- A discretionary annual bonus program or for field sales representatives a salesbased incentive plan
- Stockbased longterm incentives
- Awardwinning timeoff plans
- Flexible work models including remote and hybrid work arrangements where possible
Apply now and make a lasting impact with the Amgen team.
careers.amgen
In any materials you submit you may redact or remove ageidentifying information such as age date of birth or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
As an organization dedicated to improving the quality of life for people around the world Amgen fosters an inclusive environment of diverse ethical committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race color religion sex sexual orientation gender identity national origin protected veteran status disability status or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. Please contact us to request accommodation.
.Salary Range
147880.00 USD 173068.00 USDRequired Experience:
Staff IC
Employment Type
Full-Time
