Post Doctorate Scientist - Generative AI for Retinal Image Forecasting and Pharmacodynamic Modeling
Post Doctorate Scientist - Generative AI for Retinal Image Forecasting and Pharmacodynamic Modeling
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Job Description
At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.
The Position
A healthier future. Its what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. Thats what makes us Roche.
The Opportunity
As a Postdoctoral Fellow in the Roche Pharma Research and Early Development Data and Analytics Department you will focus on generative AI and pharmacodynamics modeling with the Ophthalmology Precision Medicine (OPM) project a cornerstone of pREDs ophthalmology strategy.
You will be working with a dedicated team of experienced scientists and clinicians to develop computer vision models capable of analyzing and predicting the timecourse of an individual patients imaging biomarker signature in order to predict disease progression response to treatment and to enable detailed insights into pharmacodynamics at the individual eye level.
The role focuses on analyzing Optical Coherence Tomography (OCT) retinal images sourced from both a home monitoring device (SCANLY Notal Vision) and clinical instruments (Spectralis Heidelberg Engineering). The initiative will be critical to differentiate products enhance market placement and demonstrate predicted treatment outcomes to physicians and patients under various scenarios ultimately improving overall clinical trial efficiency and patient outcomes.
As a postdoctoral fellow you will be supervised by scientists at Roche as well as an independent academic expert as partner. The duration of the RPF project is initially set for two years with the possibility of extension for a third year. You will be based in Basel with stays at our academic partner.
You are a PhD degree graduate in a Data Science related field (e.g. Statistics Computer Science Biomechanics Biomedical engineering). To be eligible for a Roche Postdoctoral Fellowship you must be within the first four years of completing your PhD in a relevant field at the start of the project. The RPF project is initially set for a duration of two years with the possibility of a thirdyear extension
You have experience and expertise in the following:
A PhD in a relevant field such as artificial intelligence imaging sensors biology pharmacology biomedical engineering or a related discipline
Excellent understanding of quantitative data analysis
Prior experience with applying relevant software (e.g. R Python Matlab/Simbiology... for imaging data analysis
Prior experience with generative AI in imaging such as GANs or diffusion models
Excellent communication skills with the ability to present complex information clearly
Fluency in English
Publication record demonstrating independent and creative research
Additional Experience and Competencies Preferred:
Prior experience or a good understanding of retinal biology is desirable
Prior experience with insilico modeling is a plus but the motivation to learn the basics for the application in this project is a must
A basic understanding of pharmacokinetic and pharmacodynamics in drug development is desirable
Responsibilities:
Collaborate with the host teams and other stakeholders to develop and evaluate potential analysis techniques and applications
Design build and interpret data analysis algorithms to address selected research questions including data preprocessing
Prepare scientific communication content (presentations reports conference abstracts and manuscripts) to share the results of the project with a wider community.
You have very good interpersonal skills are able to build good working relationships and are an outstanding teammate. Your experience and investigative attitude allow you to work independently to design perform and interpret experiments and to embark on new scientific methodologies.
You have been actively engaged in scientific research continuously since your PhD and are ready to start an RPF postdoctoral activity no later than 4 years after completing your PhD.
When does it start
The start date of this fellowship is in May 2024 or on availability. Please clearly indicate your preferred starting date on your motivation letter.
All applications always need to include a CV motivation letter a publication list and if available a copy of your PhD certificate.
The position is sponsored by the Roche Postdoctoral Fellowship (RPF) Programme with the ambition to build and maintain the Scientific Leadership of the future and to provide leading Roche scientists with the opportunity to collaborate with talented postdoctoral researchers and leading academic research groups from around the world. One of the key aims is to advance basic science and technologies that will be published in toprated peerreviewed scientific journals if necessary and preceded by priority patent applications.
More information about the RPF Programme: we are A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver lifechanging healthcare solutions that make a global impact. Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10700 employees from over 100 countries come together at our Basel/Kaiseraugst site which is one of Roches largest sites. Read more. Besides extensive development and training opportunities we offer flexible working options 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as childcare facilities medical services restaurants and cafeterias as well as various employee events. Roche is an Equal Opportunity Employer.
Lets build a healthier future together.
Employment Type
Full-Time
