Internship IP2TIS 2025 - For students in the field of Green Peptide Chemistry
Internship IP2TIS 2025 - For students in the field of Green Peptide Chemistry
Employer Active
Job Alert
You will be updated with latest job alerts via email
Share
Job Alert
You will be updated with latest job alerts via email
Not Disclosed
Salary Not Disclosed
1 Vacancy
Job Description
At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.
The Position
A healthier future. Its what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. Thats what makes us Roche.
Are you ready to join a global network spanning 20 countries where bright minds collaborate to tackle realworld challenges in Innovation & Sustainability Do you want to work on impactful projects shape the future and drive change from within
The Opportunity
Peptide therapeutics are rapidly gaining prominence as a new modality across varied disease areas particularly in glycemic control and body weight management through longacting incretins. This progress has sparked a significant demand for highquality peptide APIs and poses new challenges for manufacturers striving to scale production while implementing sustainable practices.
A key sustainability challenge in peptide manufacturing is the reduction of perand polyfluoroalkyl substances (PFAS). PFAS are synthetic chemicals notorious for their environmental persistence resistance to degradation and potential adverse health effects. Accumulation of these substances in living organisms is of growing ecological concern and legislative initiatives are now underway to prohibit the production and use of this class of compounds in Europe.
Peptides are conventionally manufactured via solidphase peptide synthesis (SPPS) whereby amino acids are sequentially coupled to an insoluble carrier polymer until the desired peptide sequence is obtained. Upon completion of SPPS concentrated trifluoroacetic acid (a common PFAS) is typically used to cleave the crude peptide from the solid support and remove all side chain protecting groups in one step. However due to environmental and regulatory issues transitioning to greener alternatives is highly desirable.
In light of our expanding peptide API portfolio Roches commitment to environmental stewardship and innovation in pharmaceutical development the aim of this internship project is to explore PFASfree alternatives in cleavage of peptides produced through conventional SPPS. Join our team at Roche to contribute to improving the sustainability and safety of future pharmaceutical manufacturing processes.
Key Responsibilities
You will conduct a literature review and examine novel PFASfree cleavage solutions based on reported physicochemical properties and reactivity data
You will evaluate screen and optimize innovative PFASfree cleavage conditions with comparison to standard TFAbased solutions
You will analytically monitor and evaluate the quality of the cleavage reactions using stateoftheart HPLC/UPLC and MS techniques
You will summarise your findings for presentation to peers and the broader Roche community
Learning & Growth
Gain handson experience working in a stateoftheart process development laboratory
Exposure to cuttingedge science and facilities at a renowned pharmaceutical company
Final presentations of project work to industry leaders
Professional & personal development curriculum throughout the program including networking opportunities workshops and panel discussions
Receive guidance and mentorship from expert scientists
Who You Are
You are enrolled or have completed your Masters studies at a university preferably in the fields of Chemistry Pharmaceutical Sciences or Chemical Engineering within the last 12 months and are interested in applying your knowledge in a modern working environment as part of an internship of at least 3 months and getting to know the pharmaceutical industry.
Minimum Required Experience & Qualifications
You have previous handson experience in synthetic organic chemistry. Prior experience in solidphase peptide or oligonucleotide synthesis is highly desirable
You have handson experience working with analytical HPLC and MS systems
You have strong analytical and problemsolving skills to address complex scientific questions and challenges
You show meticulous attention to detail to ensure the accuracy and quality of research outputs
You are proficient in English German is a plus
Finally we are looking for passionate candidates ready to tackle realworld challenges in green chemistry to drive meaningful change. If this opportunity speaks to you then please consider applying to be part of a team that is committed to sustainability innovation and improving global health. Join us and help shape a better future for people worldwide.
If you meet most but not all qualifications we still encourage you to apply.
Technical details:
The start date for the internship is between 1st and 16th of July 2025
More information about the program you can find on go.roche/ip2tis25.
Who we are
A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver lifechanging healthcare solutions that make a global impact.
Lets build a healthier future together.
Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10700 employees from over 100 countries come together at our Basel/Kaiseraugst site which is one of Roches largest sites. Read more.
Besides extensive development and training opportunities we offer flexible working options 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as childcare facilities medical services restaurants and cafeterias as well as various employee events.
Roche is an Equal Opportunity Employer.
Required Experience:
Intern
Employment Type
Full-Time
