Post-Doctoral Research Fellow - Therapeutic Protein Design
Post-Doctoral Research Fellow - Therapeutic Protein Design
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Job Description
Overview
Fred Hutchinson Cancer Center is an independent nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle Fred Hutch is the only National Cancer Institutedesignated cancer center in Washington.
With a track record of global leadership in bone marrow transplantation HIV/AIDS prevention immunotherapy and COVID19 vaccines Fred Hutch has earned a reputation as one of the worlds leading cancer infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology infusion radiation proton therapy and related services and network affiliations with hospitals in five states. Together our fully integrated research and clinical care teams seek to discover new cures to the worlds deadliest diseases and make life beyond cancer a reality.
At Fred Hutch we value collaboration compassion determination excellence innovation integrity and respect. Our mission is directly tied to the humanity dignity and inherent value of each employee patient community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems.
The Ring Lab of Synthetic and Systems Immunopharmacology is located within the Translational Science and Therapeutics Division and is a member of the Immunotherapy Integrated Research Center (IIRC). Their primary focus is on developing unique and firstinclass therapeutic for cancer immunotherapy using cuttingedge protein engineering with directed evolution. The lab has developed therapeutics that are currently in clinical trials such as ST067 (a decoyresistant IL18 MDNA11 (CD122biased IL2 and ALX148/evorpacept (an ultrahigh affinity SRP decoy). Moreover the Ring Lab is actively working on developing platforms for identifying new targets in cancer immunotherapy. These technologies include the REAP platform for discovering autoantibodies in patient samples and highthroughput techniques in synthetic antibody engineering and proteogenomics to pinpoint new tumor antigens.
Responsibilities
The Ring Lab is recruiting a PostDoctoral Research Fellow with expertise in immunology systems/computational biology and/or protein engineering. This position will involve research projects that investigate the relationship between patient autoantibodies and health and disease outcomes. At the core of these programs is the REAP autoantibody profiling technology which provides unprecedented levels of detail about the autoantibody reactome present in patient blood and tissue samples. Researchers will perform the very first autoantibodywide association studies to pinpoint how specific autoantibody reactivities impact disease biology analogous to but independent from the effect of genetic variation. This entirely new research program is poised to identify novel therapeutic targets for a range of indications including cancer autoimmune disease inflammatory conditions such as IBD infectious disease and neurodegeneration.
The ideal candidate will be a highlycurious motivated independent and collaborative research scientist keen to explore new areas of biology and therapeutic development. They will work closely with Dr. Ring lab manager Alison Notestine external collaborators and other members of the Ring laboratory to execute highlymultidisciplinary studies. Furthermore they will have the opportunity and responsibility to contribute to the preparation of research reports and scientific manuscripts as well as present at scientific conferences and symposiums. The Ring lab welcomes candidates with a diverse range of career aspirations and has a trackrecord of supporting trainees to pursue careers in academia biotech/pharma lifescience investing and consulting.
Qualifications
MINIMUM QUALIFICATIONS:
- MD or PhD in a related field
- Broad experience in molecular and cell biology methods and the ability to master new techniques and approaches
- Excellent verbal and written communication skills
- A team player with strong aptitude for collaboration
PREFERRED QUALIFICATIONS:
- Experience in one or more of the following areas:
- Immunology
- Systems biology/bioinformatics
- Single cell transcriptomics/proteogenomics
- Protein engineering/directed evolution with yeast phage or mRNA/ribosome display technology
- Experience with mouse models is desirable
The annual base salary range for this position is from $77976 to $95014.40 and pay offered will be based on experience and qualifications.
This position may be eligible for relocation assistance.
Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health wellbeing and financial security. Benefits include medical/vision dental flexible spending accounts life disability retirement family life support employee assistance program onsite health clinic incomebased child care subsidy tuition reimbursement paid vacation 22 days per year) paid sick leave (up to 30 calendar days per occurrence of a qualifying reason) paid holidays 13 days per year) and paid parental leave (up to 4 weeks).
Additional Information
Employment Type
Full-Time
