Postdoctoral Fellow
Postdoctoral Fellow
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Job Description
Salary for this Role:
From 43210 with benefits subject to skills and experience
Job Title:
Postdoctoral FellowReports to:
Rashmi PriyaClosing Date:
29/Apr/2025 23.59 GMTJob Description:
Postdoctoral Fellow
Details of the role: Fixed term for 4 years fulltime. The position is offered for 4 years but can be extended for a further 2 years 6 years in total).
We encourage you to apply as soon as possible. If the position remains unfilled we may continue to advertise on a rolling basis.
About us
The Francis Crick Institute is Europes largest biomedical research institute under one roof. The Crick is a place for collaboration innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with stateoftheart infrastructure cuttingedge facilities and a creative and curious culture. Weve removed traditional boundaries of departments divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out highquality pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.
About the role
We are seeking a postdoctoral fellow interested in combining interdisciplinary approaches with excellent tractability of the zebrafish heart to study a longstanding problem how organ form and function emerge during development. Some of the fundamental questions we seek to address include
1 Feedback between mechanics cell fate dynamics and geometry driving tissue patterning
2 How 3D topological meshworks are shaped constrained and canalized
3 How nuclear integrity is sustained in a developing beating hear
4 Morphogenesis and Mechanics of organ scaling and regeneration
5 Bioelectricity of Morphogenesis.
The suitable candidate will utilize advanced microscopic techniques image analysis genetic manipulations biophysical approaches and collaborate with theoreticians to address these questions. The specific details and aims of the project will be driven by the candidates interest and training. Candidates with a strong background in advanced imaging approaches image analysis techniques tissue morphogenesis/mechanics are encouraged to apply.
What you will be doing
The overarching goal of our lab is to study how functional organs are built to sustain life during embryonic development. This is a longstanding problem in biology with significant implications for tissue engineering and birth defects. To solve this fundamental problem we use a wellsuited model system the developing zebrafish heart as it is amenable to stateoftheart optical biophysical and genetic manipulations. We take a systems biology approach by integrating tools from tissue mechanics developmental genetics transcriptomics biophysics and predictive theoretical modelling. Using these approaches we dissect the morphogenesis of complex organs like the heart in exceptional detail within the physiological context of a living embryo.
A key step during vertebrate heart development is chamber maturation a poorlyunderstood morphogenetic process critical for heart function. During this process the myocardial wall of the ventricle and atrium transforms from a singlelayered epithelium into a complex 3D topological meshwork architecture. In the ventricle these meshworklike structures are called trabeculae while in the atrium they are referred to as pectinate fibers. Anomalous morphology and patterning of these structures lead to embryonic lethality and cardiomyopathies in humans. Yet cellular and physical mechanisms building and rebuilding this myocardial meshwork remain poorly understood. Combining the excellent tractability of zebrafish with interdisciplinary approaches some of the fundamental questions we seek to address include:
1 Feedback between mechanics cell fate dynamics and geometry driving tissue patterning
2 How 3D topological meshworks are shaped constrained and canalized
3 How nuclear integrity is sustained in a developing beating hear
4 Morphogenesis and Mechanics of organ scaling and regeneration
5 Bioelectricity of Morphogenesis.
You will address one of these questions using advanced microscopic techniques image analysis genetic/optical manipulations biophysical approaches and in collaboration with theoreticians. The specific details and aims of the project will be driven by your interest and training. If you have a strong background in advanced imaging approaches image analysis techniques tissue morphogenesis/mechanics we encourage you to apply.
About you
You will bring
- PhD in developmental biology/biophysics/ cell biology or in the final stages of PhD submission.
- Strong expertise in advanced confocal and/or light sheet imaging.
- Strong expertise in quantitative image analysis approaches.
- Excellent molecular biology skills.
- Strong interest and experience in using interdisciplinary approaches in their research program.
- Excellent written and oral communication skills.
To see the complete job description click here.
To see more about team/Group Leader click here.
About Working at the Crick
Our values
Everyone who works at the Crick has a valuable role to play in advancing the Cricks mission and shaping our culture!
- We arebold. We make space for creative dynamic and imaginative ideas and approaches. Were not afraid to do things differently.
- We areopen. Were highly collaborative and interactive and make sure our activities are visible to the outside world.
- We arecollegial. We show respect for one another work cooperatively and support the wider community.
At the Francis Crick Institute we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued respected and empowered to succeed regardless of their background identity or personal circumstances. We actively encourage applications from individuals of all genders ethnicities abilities and experiences. We want to ensure that everyone can apply and be part of our recruitment processes and so well make reasonable adjustments if you need them just let us know when you apply. If you need assistance with applying (i.e. would like to apply by phone or post)please email:
To find out more about life at the Crick click here.
What will you receive
At the Francis Crick Institute we value our team members and are proud to offer an extensive range of benefits to support their wellbeing and development:
- Visas: Applicants for this role will be eligible for sponsorship to work in the UK
- Generous Leave: 28 days of annual leave plus three additional days over Christmas and bank holidays.
- Pension Scheme: Defined contribution pension with employer contributions of up to 16.
- Health & Wellbeing:
- 24/7 GP consultation services.
- Occupational health services and mental health support programs.
- Eye care vouchers and discounted healthcare plans.
- WorkLife Balance:
- Backup care for dependents.
- Childcare support allowance.
- Annual leave purchase options.
- Crick Networks offering diverse groups support community and inclusive social events.
- Perks:
- Discounted gym memberships biketowork scheme and shopping discounts.
- Subsidised onsite restaurant and social spaces for team interaction.
- Development & Recognition: Comprehensive training mentoring and a pay structure with performancelinked progression.
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities regardless of ethnicity nationality gender sexual orientation gender identity religion pregnancy age disability or civil partnership marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institutes success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity respect inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies policies and practices.
Employment Type
Grant
Key Skills
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