Post-Doc Research Associate-Bhatt Lab

Position Summary
The Bhatt Lab at UNC Chapel Hill is seeking motivated talented and creative scientists with demonstrable bioanalytical expertise to join our team. In our lab we are advancing precision medicine by studying the gut microbiome which contributes to interindividual variability in drug responses including efficacy and toxicity. By studying bacterial drug metabolism we will develop strategies to predict and prevent druginduced injury and reduce medication side effects thus promoting public health. The candidate will have a strong background in bioanalytical techniques and method development using a variety of platforms including but not limited to LCMS/MS HPLC etc. The central role for the candidate is in developing assays to quantify metabolites of drug metabolism generated by gut microbes and the host using tandem LCMS/MS methodology. The candidate will also provide support for method development to the UNC Dept. Of Mass Spectrometry Core laboratory directed by Dr. Brandie Ehrmann.

Required Qualifications Competencies And Experience
Required Competencies: The Research Scientist will design and perform experiments analyze and interpret data and disseminate research findings through written manuscripts grant applications and oral presentations. This role includes a significant focus on quantitative mass spectrometry requiring expertise in handling and analyzing complex datasets. The ideal candidate will have a strong background in mass spectrometry and wet lab techniques along with experience in mentoring and training undergraduate students. Key Responsibilities: Experimental Design & : Design and conduct experiments with a focus on quantitative mass spectrometry. Perform sample extraction and preparation from biological matrices. Data Analysis & Interpretation: Analyze and interpret complex data sets including quantitative mass spectrometry data. Utilize modern mass spectrometry equipment and software. Research Dissemination: Prepare and present research findings through written manuscripts grant proposals and oral presentations at lab meetings local national and international conferences. Mentorship: Work effectively with undergraduate students providing training and guidance in laboratory techniques and data analysis. Equipment Management: Troubleshoot and maintain mass spectrometry and chromatography equipment. Ensure the proper functioning of laboratory instruments. Independent Problem Solving: Address and resolve experimental challenges independently. Relate experimental outcomes to the broader research context. Protocol Development: Read and interpret published manuscripts and experimental protocols adapting methods for laboratory use. Qualifications: Education: Ph.D. in Chemistry Pharmacology Analytical Chemistry and/or a related field with recent experience in a research laboratory. Mass Spectrometry Expertise: Knowledge of modern mass spectrometer equipment and software from various vendors. Recent handson experience with mass spectrometry. Wet Lab Experience: Proficiency in pipetting sample extraction and sample preparation from biological matrices. Data Handling: Experience working with large datasets particularly those derived from mass spectrometrybased analyses. Independence & Problem Solving: Demonstrated ability to work independently and solve complex experimental problems. Communication Skills: Ability to present research findings clearly and effectively in both written and oral formats. Experience with manuscript preparation and grant writing. Training & Mentorship: Proven ability to train and work constructively with diverse individuals including laboratory personnel. Flexibility: Willingness to work occasional long hours as research demands. Required Experience: prior wet lab experience in pipetting sample extraction and sample preparation from biological matrices techniques preferred.

Preferred Qualifications Competencies And Experience
Designing and performing experiments analyzing and interpreting data disseminating research through written (manuscripts grant applications poster presentations) and oral presentations at lab meetings local/national/international conferences. Should be able to work with undergraduate students. Preferred Experience: prior wet lab experience required. Previous experience working in drug metabolism intestinal biology/physiology epithelial biology/physiology or stem cell biology/physiology. Prior experience operating mass spectrometry and liquid chromatography instrumentation. Quantitative mass spectrometry experience utilizing tandem mass spectrometers is a significant bonus.