RTP Research Fellow - Psychology
RTP Research Fellow - Psychology
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Salary Not Disclosed
1 Vacancy
Job Description
This study is designed to identify novel therapeutics for substance use disorders. We will apply novel network biology approaches pathway modeling and simulation computational tools to prioritize potential candidates for functional genomic studies. The approaches we are taking could help us to develop mechanistic hypothesis for experimental validation. Our findings will enhance the general understanding of drug mechanism(s) of action and the underlying the pathophysiology responsible for substance use disorders thus opening new avenues for discovering novel therapeutic targets for the treatment of substance use disorders.
Dr. Hos laboratory has established protocols for differentiating human iPSCs into a variety of cell types including neurons astrocytes and brain organoids and has developed cellular models and cell therapeutic candidates for diseases including alcohol use disorder and opioid use disorder.
Qualifications
Basic education experience and skills required for consideration:
- The successful applicant should have completed a PhD or MD in biology neuroscience pharmacology or a related field. While ideal candidates should have expertise in one of the following areas we also appreciate candidates in other fields who are committed to learning new skills and keen to bring their unique expertise to study neuropsychiatric disorders in a collaborative environment.
- The ability to work independently to participate in highly collaborative projects and to contribute intellectually to the development of the research and process development are requisites for this position.
- Experience in basic fundamental molecular biology techniques (such as gel electrophoresis Western blotting qPCR molecular cloning CRISPR editing plasmid construction virus packing iPSC culture RNAsequencing multiomics studies).
- Candidates are expected to lead a project and establish collaborative research and must have excellent verbal and written communication skills.
Key Responsibilities include:
- The postdoctoral fellow will lead a project on human iPSCbased disease modeling and therapeutic development for neuropsychiatric disorders such as alcohol use disorder and opioid use disorder.
- The postdoctoral fellow is expected to write progress reports and highquality manuscripts for publication. Applying for postdoctoral fellowship and participating in grant applications are encouraged.
- Dr. Ho will provide training for iPSC generation and maintenance and lab techniques for functional genomic studies. The postdoctoral fellow will be responsible for routine cell culture for iPSCs and brain organoids i.e. these cells require renew culture media daily. The postdoctoral fellow will use the data generated from the scRNAseq and generate hypothesis and test in the lab. She/he will work closely with Dr. Ho for this grant to pursue the function and mechanisms of genes and pathways identified in the course of this project. She/he will have their own projects and build their bibliography during their postdoctoral training.
Employment Type
Full-Time
