Postdoctoral Researcher or Research Associate-Zhou lab
Postdoctoral Researcher or Research Associate-Zhou lab
Employer Active
Job Alert
You will be updated with latest job alerts via email
Share
Job Alert
You will be updated with latest job alerts via email
$ 71845 - 82000
1 Vacancy
Job Description
Cellular and organismal aging using Drosophila as a model system
POSITION SUMMARY
The Zhou lab at the Buck Institute has an opening for aPostdoctoralResearcherorResearch Associatetostudy the connection between cellular and organismal aging neuroscience & behavior as well as agerelated diseases (e.g. AD and ALS) using fruit flies as a model.
Cellular aging with conserved hallmarks including proteostasis defect mitochondrial/lysosomal dysfunction and epigenetics changes is well studied among different cell types. However beyond these cellular aging phenotypes the mechanism that leads to organismallevel aging including cognitive function decline gastrointestinal track malfunction and stress vulnerability is less understood.
The Zhou lab which has a wellestablished system to study aging mechanisms at the cellular level recently started to systematically understand how cellular aging leads to organismal aging. We adopt Drosophila as a model system to study how aging hallmarks in different cell types (e.g. neurons) contribute to organismal aging. In addition to powerful genetics in Drosophila we leverage an array of cuttingedge techniques encompassing advanced imaging methods behavior screening biochemistry and machine learning to assay physiological aging.
Our objective is for you to succeed and publish highprofile papers that will help you fulfill your future career goals. This is a great time to join our lab since one of several ongoing fly projects is wrapping up. Please check theZhou lab webpagefor recent publications.
QUALIFICATIONS
- Previous research experience working with fruit flies is preferred but not required
- Strong interest in cell biology behavior and aging
COMPENSATION & BENEFITS
- 2024 Postdoc salary range: $71845 $82000 commensurate with level & experience; Research Associate salary range: $50000 $85000 commensurate with education & experience
- Exciting dynamic work environment at the forefront of science using stateoftheart techniques
- Generous benefits package including health insurance paid parental leave generous vacation and 401(k) with a 5 employer match and student loan repayment option
- Collaborative environment both for science and social activities
TO APPLY
Please submit a cover letter addressing your past research experience plans and expectations for working in the lab. Also include 12 paragraphs on specific questions related to topics that you would like to pursue in our lab. This short research proposal will help us focus our time on the candidates that best match our lab interests. Please also upload a current CV and 3 professional references.Please feel free to consult me via email emailprotected.
ABOUT THE BUCK
Our success will ultimately change healthcare. At the Buck we aim to end the threat of agerelated diseases for this and future generations by bringing together the most capable and passionate scientists from a broad range of disciplines to identify and impede the ways in which we age. We are an independent nonprofit institution located in Marin County CA with the goal of increasing human healthspan or the healthy years of life. Globally recognized as the pioneer and leader in efforts to target agingthe number one risk factor for diseases including Alzheimers Parkinsons cancer macular degeneration heart disease and diabetesthe Buck seeks to help people live better longer. The Buck Institute has an excellent postdoctoral research program. We offer competitive salaries excellent benefits a dynamic work environment and new stateoftheart facilities.
Related publications
Liu Q. et al. 2023. Nascent mitochondrial proteins initiate the localized condensation of cytosolic protein aggregates on the mitochondrial surface.Proc Natl Acad Sci USA. 2023 Aug; 12031 e
Zhou C. The molecular and functional interaction between membranebound organelles and membraneless condensates.Front. Cell Dev. Biol.Apr 25;10:896305.
Liu Q. et al. 2022. Tom70 regulates the transcription of nuclearencoded mitochondrial proteins.eLife.2022 Mar 2;11:e75658.
Domnauer M. et al. 2021. Proteome plasticity in response to persistent environmental change.Mol Cell.8116:.
Ruan * Zhou C.* et all. 2017. Cytosolic Proteostasis through Importing of Misfolded Proteins into Mitochondria.Nature.*equal contribution)
Zhou C. et al.Organellebased Aggregation and Retention of Damaged Proteins in Asymmetrically Dividing Cells.Cell.
Zhou C. et al.Motility and Segregation of Hsp104associated Protein Aggregates in Budding Yeast.Cell147:.
Required Experience:
Senior IC
Employment Type
Full-Time
