Senior Director Head Of Advanced Cell Models
Senior Director Head Of Advanced Cell Models
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Job Description
SENIOR DIRECTOR HEAD OF ADVANCED CELL MODELS
Location: Boston MA Cambridge UK Gothenburg SE Gaithersburg MD
At AstraZeneca we push the boundaries of science to deliver lifechanging medicines. Our global Safety Sciences organization delivers innovative nonclinical safety science and toxicology expertise to enable the discovery development and registration of novel medicines.
As a sciencedriven business we continuously strive to innovate to enhance our scientific capabilities and accelerate the speed at which we bring medicines forward.
Advanced cell models (ACMs) such as organoids and microphysiological systems provide New Alternative Methods (NAMs) for safety assessment and to study disease biology. We are playing a leading role in the field to apply ACMs to drug discovery and development in particular to predict and optimize therapeutic index for novel candidate .
To enhance our ACM strategy we are looking to recruit a Senior Director Head of Advanced Cell Models Safety Sciences.
The role can be based at any of our R&D sites in Boston MA (US) Cambridge (UK) Gothenburg (Sweden) or Gaithersburg MD (DC metro area US) it is part of the Safety Sciences Leadership Team and reports to the VP Global Head of Safety Sciences.
Job description:
Accountable for defining and executing a strategy for the use of advanced cellular models to impact drug discovery and development decision making in particular to humanize prediction of therapeutic index and to replace and refine both preclinical and clinical studies.
Direct line and matrix leadership to deliver (i) approaches to optimize prediction of therapeutic index integrating highdimensional and systems modelling data for AstraZeneca portfolio discovery and development stage assets (ii) exploration of new technology for advanced cell models including scaling and/or automation and efficient data management and (iii) partnerships with internal stakeholders and external consortia and health authorities to qualify validate and gain acceptance of NAMs in accordance with for example FDA modernization Act 3.0.
Provide leadership across Clinical Pharmacology and Safety Sciences and across partner R&D functions driving effective collaboration to deploy existing and novel capabilities to influence drug discovery and development decisions across therapeutic areas.
Address current needs and anticipate future capability gaps and technology demands to solve the critical needs of our diversifying portfolio across therapeutic areas and modalities.
Influence and leverage the advancement across in vitro and in silico science to accelerate application of ACMs and NAMs.
Impact internal and external understanding how ACMs and NAMs can support 3Rs objectives support legislative requirements drive ethical and sustainability objectives towards societal and regulatory acceptance to refine and replace traditional methods.
Forge dynamic industry network partnerships and collaborations (including crosssector collaboration) with leading academic centers and subject matter experts to shape and align with emerging health authority requirements.
Qualifications that apply to the role:
Strong academic background with PhD in a relevant field (Cell Biology Engineering Pharmacology Toxicology or related discipline) with high quality publications.
Robust understanding of drug discovery and development across therapeutic areas and drug modalities.
Track record of scientific innovation leading development and application of cuttingedge novel science.
Excellent understanding of ACMs and NAMs (including organoids MPS in silico modelling) 3Rs and regulatory requirements for drug development.
Demonstrated strong leadership skills in a complex matrix organization and line management experience with a track record in the leadership management and talent development of individuals and teams fostering an inclusive culture driving performance and development and effective collaboration.
Excellent influencing communication and presentation skills ability to work across scientific disciplines and bridge organizational boundaries.
Track record of securing internal / external research investments and leading dynamic and crossfunctional collaboration as well as with academia biotech pharma industry and CRO partners.
US ONLY FOR PAY TRANSPARENCY
The annual base pay (or hourly rate of compensation) for this position ranges from 213640..00 USD Annual. Hourly and salaried nonexempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors including market location jobrelated knowledge skills and experience. In addition our positions offer a shortterm incentive bonus opportunity; eligibility to participate in our equitybased longterm incentive program (salaried roles) to receive a retirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an atwill position and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and market factors.
Date Posted
10Mar2025Closing Date
04Apr2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Exec
Employment Type
Full-Time
