Sr Associate Scientist Upstream Polysaccharide Process Development
Sr Associate Scientist Upstream Polysaccharide Process Development
Posted on :
15-03-2025
Employer Active
1 Vacancy
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Monthly Salary
$ 111000 - 128000
Vacancy
1 Vacancy
Posted on :
15-03-2025
Job Description
Join our Mission to Protect Humankind!
Vaxcyte is a clinicalstage vaccine innovation company engineering highfidelity vaccines to protect humankind from the consequences of bacterial diseases which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease Group A Strep periodontitis and Shigella is just the beginning. Our path to success is clear and welldefined and Vaxcyte is set up to go the distance.
WHAT we do is every bit as important as HOW we do it!Our work together is guided by four enduring core values:
*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and reinnovate the way vaccines are delivered.
*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.
*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindnessfirst inclusive approach to collaboration and vigorous debate that advances our business objectives.
*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity accountability equality and clarity across communications and decision making.
Summary:
The Development organization is comprised of four Process teams: Protein Polysaccharide Conjugate Drug Substance (Conjugation) and Drug Product. These Process Development teams are supported by Analytical Development and Formulation Development teams. Vaxcyte is looking for a Senior Associate Scientist with experience in microbial fermentation and upstream processing to join the Upstream Polysaccharide Process Development team. The candidate will be responsible for collaboration on experimental design and of experiments to further develop and optimize upstream processes for polysaccharide manufacturing using microorganisms. The successful candidate will have practical laboratory experience related to microbial fermentation processes and eager to utilize and learn new laboratory skills. The role will require >50 time in the lab and this person will be able to independently detail experimental procedures/results in written and presentation formats. The successful candidate may interface closely with the crossfunctional team write detailed technical reports present experimental results internally and may potentially interface with external CMO partners.
Essential Functions:
- Support in study design execute and analyze experiments for upstream polysaccharide for bacterial fermentation (BSL2 and vaccine production processes.
- Execute experiments to develop the upstream process parameters (e.g. media feed pH temperature dissolved oxygen agitation etc. and to enhance product yield quality and consistency.
- Perform microbiology related work including plating colony selection Gram staining and cell enumeration on microscope.
- Perform fermentation vessel assembly and script writing for process automation and execute fermentation experiment in shakeflask and lab scale bioreactors.
- Prepare media and buffer as needed for experiments.
- Operate and maintain instrumentation for bacterial fermentation and primary recovery (centrifugation filtration etc. of bacterial polysaccharides utilizing aseptic techniques.
- Support analytical method including optical density residual metabolites and polysaccharide concentration and other relevant analytical techniques.
- Assist in executing latestage process development studies including process characterization.
- Keep accurate and current records of research and/or project related activities in laboratory notebooks and Electronic Lab Notebook.
- Prepare and review protocol technical reports SOPs and batch records.
- Present and communicate scientific data and results to internal stakeholders.
- Be an outstanding teammate and collaborate effectively with downstream analytical and manufacturing teams within Polysaccharide Development and Manufacturing team to ensure seamless technology transfer and process integration.
Requirements:
- MSc in Chemical/Biochemical Engineering Biotechnology or similar degree with a minimum of 3 years of relevant industry experience or BSc with a minimum of 5 years of relevant industry experience.
- Experience in handling microorganisms with proper aseptic techniques to perform upstream processing related work in flasks/bioreactors.
- Handson experience and theoretical understanding of key processing operations such as microbial culture fermentation process microbial media and process optimization and relevant analytical technologies; experience with depth filtration continuous centrifugation is a plus.
- Develop and optimize scripts for instrumentation including Ambr systems to enhance efficiency and automate processes leveraging programming languages such as Python or R is a plus.
- Experience with Design of Experiments (DoE) principles and DoE software.
- Process characterization experience is a plus.
- Cell banking expertise colony selection and genetic analysis of recombinant strains is a plus.
- Proficiency with computer programs such as Microsoft Excel Word PowerPoint Visio and JMP.
- Working knowledge of GMP requirements.
- Proven ability to succeed in a crossfunctional team environment effectively managing multiple projects and contributing to team outcomes.
- Strong interpersonal skills with excellent written and verbal communication abilities.
Reports to: Director Upstream Polysaccharide Process Development
Location: San Carlos CA
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $111000 $128000
Send resumes to:
Vaxcyte Inc.
825 Industrial Road Suite 300
San Carlos CA 94070
We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race color religionsex sexual orientation gender identity national origin disability or veteran status.
Required Experience:
Senior IC
Employment Type
Full-Time
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