Sr Associate Scientist Chem Mol Therapeutics
Sr Associate Scientist Chem Mol Therapeutics
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Job Description
About This Role
The BioDesign Protein Biohemistry group at Biogen is seeking a creative and selfmotivated scientist to contribute to our mission to design and develop medicines to transform patients lives. The successful candidate will play a key role in designing generating and characterizing antibodyoligonucleotide conjugates intended to improve the delivery of therapeutic oligonucleotides (ASOs or siRNAs) to target tissues. This role requires a strong background in protein chemistry with extensive experience in bioconjugation and a deep understanding of linker design and optimization to improve the stability efficiency and efficacy of antibodyoligonucleotide conjugates.
What Youll Do
Optimize and implement protein purification schemes for engineered antibodies using computerinterfaced chromatography systems (e.g. AKTA or similar)
Characterize proteins using standard methods such as SDSPAGE analytical sizeexclusion chromatography and dynamic light scattering
Work with a crossfunctional team to design and test novel linker chemistries to enhance conjugate stability and performance
Develop and optimize novel antibodyoligonucleotide conjugation and purification methods
Generate purify and analyze antibodydrug conjugates for use in animal models.
Actively contribute to project strategy and experimental design and regularly present findings at team meetings
Troubleshoot technical challenges and drive continuous improvements in conjugation and purification workflows
Who You Are
The ideal candidate has a strong background in bioconjugation methods a passion for science and a genuine enthusiasm for collaborating within a crossfunctional team.
Qualifications :
Required Skills
Ph.D. in biochemistry chemical biology chemistry or a related field with 02 years experience or a Masters degree with 4 years relevant industry experience.
Extensive experience in protein purification including method development.
Strong analytical skills and proficiency with standard protein characterization methods (e.g. SDSPAGE sizeexclusion chromatography and DLS).
Experience with antibodyoligonucleotide conjugation techniques including clickchemistry and sitespecific methods.
Demonstrated ability to independently design plan execute and interpret complex experiments.
Excellent written and verbal communication skills.
Preferred Skills
Experience with linker design
Experience with antibodyoligoconjugate quantitation and stability assays
Additional Information :
The base salary range for this position is $122000 $163000. Base salary offered is determined though an analytical approach utilizing a combination of factors including but not limited to relevant skills & experience job location and internal equity. Regular employees are eligible to receive both short term and longterm incentives including cash bonus and equity incentive opportunities designed to reward recent achievements and recognize your future potential based on individual business unit and company performance.
In addition to compensation Biogen offers a full and highly competitive range of benefits designed to support our employees and their families physical financial emotional and social wellbeing; including but not limited to:
- Medical Dental Vision & Life insurances
- Fitness & Wellness programs including a fitness reimbursement
- Short and LongTerm Disability insurance
- A minimum of 15 days of paid vacation and an additional endofyear shutdown time off (Dec 26Dec 31
- Up to 12 company paid holidays 3 days off for Personal Significance
- 80 hours of sick time per calendar year
- Paid Maternity and Parental Leave benefit
- 401(k) program participation with company matched contributions
- Employee stock purchase plan
- Tuition reimbursement of up to $10000 per calendar year
- Employee Resource Groups participation
Why Biogen
We are a global team with a commitment to excellence and a pioneering spirit. As a midsized biotechnology company we provide the stability and resources of a wellestablished business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning growth and expanding their skills. Above all we work together to deliver lifechanging medicines with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds cultures and perspectives make us a stronger and more innovative company and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.
All qualified applicants will receive consideration for employment without regard to sex gender identity or expression sexual orientation marital status race color national origin ancestry ethnicity religion age veteran status disability genetic information or any other basis protected by federal state or local law. Biogen is an EVerify Employer in the United States.
Remote Work :
No
Employment Type :
Fulltime
Employment Type
Full-time
