Director Immune Monitoring and Therapeutic Analytics
Director Immune Monitoring and Therapeutic Analytics
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Job Description
Department Overview
The OHSU Knight Cancer Institute known as one of the pioneers in personalized cancer medicine is an international leader in research and cancer treatment. Driven by its mission to end cancer as we know it the institute is building upon its expertise in targeted treatments to advance the early detection of cancer when the disease is most treatable.
Every Knight Cancer employee is expected to embody our guiding principles:
- We act BOLDLYBreakthroughs require pushing the boundaries of science exploring new frontiers and thinking differently
- We SUPPORT each otherRespect leads to trust which leads to excellence
- We work as a CONNECTED team We must leverage our collective brain power to conquer cancer because no one individual can do it alone
Function/Duties of Position
This director position will be responsible for scientific oversight strategic planning and day to day operations of the Immune Monitoring and Cancer Omics (IMCO) Laboratories at the Knight Cancer Institute. The director will be responsible for formal implementation of the IMCOs mission which is to provide state of the art technologies to internal and external research and clinical collaborators. Together with KDLs Senior Director of Operations the position will be responsible for defining program offerings determining the need for and implementing new offerings ensuring a streamlined engagement processes with customers unifying reporting tools/analytics and overall coordination of the program. In this role the director will engage with potential internal and external clients including pharmaceutical companies research institutes healthcare centers and other relevant partners. The director will drive the scientific success of these collaborations and importantly serve as the organizational focal point for the program. Additionally she/he will serve as the primary point of contact representing the Knight Cancer Institute and OHSU. This position will report to the Senior Director of Operations at the Knight Diagnostic Laboratories and have a dottedline reporting to the IMCO scientific governance board.
In support of the IMCO program this position will work closely with several core facilities and academic research stakeholders with the goal of providing a unified gateway to their services and thereby best meet the translational research needs of the clients. The director must have sufficient knowledge and experience in the areas of cancer biology and immunology as well as advanced understanding of data analysis. Some handson lab experience in either computational analysis and/or laboratory techniques is strongly desired. Strong leadership skills the ability to meet deadlines research goals and milestones are essential. Serving as a liaison between the scientific board business development team and potential clients this position will be responsible for directly overseeing all IMCO projects.
Duties include:
- Define develop and review initial and ongoing program offerings unify reporting tools/analytics used and coordinate overall of the IMCO program such that it functions as a singleentry point for customers.
- Oversee an innovative crossfunctional team that will work together under the IMCO platform to build and execute academic biotech and pharmaceutical projects.
- Engage in hands on of IMCO offerings in the lab helping to optimize and run or analyze patient data.
- Develop and implement scope of work for all projects and clients including milestone tracking and data delivery. Establish individual project scientific and operational goals in a detailed and standardized fashion.
- Establish a relationship with basic and clinical research investigators integrating IMCOs research platform into clinical trials and basic research labs including education of potential customers on optimal use of the IMCO program to support basic and translational research.
- In collaboration with KDL and Knight Biolibrary establish and develop protocols for data handling and biospecimen procurement and storage.
- Identify roles needed develop job descriptions and oversee hiring for critical FTEs for the program and help with their integration into the workflow.
- Develop and streamline the analytics for all assays for mIHC cyCIF scRNAseq and CyTOF and other assays such as NanoString GeoMx DSP and other NGS based assays.
- Lead the bioinformatics team to develop automated analytics pipelines establish new data visualization algorithms streamline and standardize reports and deliverables in a professional wellorganized format.
- Provide scientific insight for generated assay reports including observations data interpretation and clinically relevant recommendations.
- Lead the effort on generation and implementation of a GLPlike research standards across all research assays including operational due diligence with external clients such as Astra Zeneca.
- Work together with IMCOs program manager to continue to development and implement standardized SOPs and operational flows (including specimen receipt handling and tracking QM plan document control BEMs and others).
Required Qualifications
- Masters or PhD required AND 5 years of experience. OR Bachelors and 7.
- Proficient and comfortable with a highly diversified multidisciplinary work environment demonstrating ability to simultaneously drive multiple complex projects
- Proficient knowledge of cancer biology and immunology in the context of cancer clinical trials
- Minimum of 35 years of experience engaging academic researchers clinicians and industry partners in effective communication to collaborate on complex translational projects
- Thorough knowledge of clinical trials structure and design including a detailed understanding of human research sample procurement and handling
- Ability to interact professionally with all levels of OHSU and partner organizations from frontline staff to highlevel executives
- Ability to manage high volume information flow of scientific concepts in a very organized and timely manner
- Demonstrate excellent communication analytical and organizational skills while working independently and as part of a team while being collaborative in resolving problems
- Ability to use tact and diplomacy to maintain effective working relationships. Proficiency with computers and MS Office suite
Preferred Qualifications
- PhD in Cancer Immunology or PhD in Computational Biology
- High proficiency in development and implementation of spatial transcriptomics and single cell data processing and analysis
- Ability to build and implement highthroughput and automated analysis pipelines
- In depth knowledge of R or Python computer language
Additional Details
Apply online. Please be sure to upload a Cover Letter and Resume/CV.
We offer a variety of benefits on top of joining a thriving organization:
- Medical dental and vision coverage at no or low cost to employees
- Covered 100 for fulltime employees and 88 for dependents
- Several retirement plans to choose from with contributions from OHSU
- 25 days a year of paid time off
- 8 days of sick time off
- Commuter subsidies
- Tuition reimbursement
- Access to group life insurance disability insurance and other supplemental benefits
- Annual Merit Increase
- Growth/Development Opportunities
- Employee discounts to local and major businesses
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All are welcome
Required Experience:
Director
Employment Type
Full-Time
