Postdoctoral Researcher Clinical and translational bioinformatics
Postdoctoral Researcher Clinical and translational bioinformatics
Posted on :
13-03-2025
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Job Description
VHIR offers a position for a Postdoctoral researcher in the development of Interpretable Pathogenicity Predictors and cellular AI models for Breast Cancer within Clinical and Translational Bioinformatics Group to participate in the project: Hacia una mejor aplicabilidad de la Inteligencia Artificial en Medicina Genmica: Integrando capacidad predictiva e interpretabilidad en una nueva generacin de herramientas para la anotacin de variantes de protenas file number: PIDOBI00 financed by Ministerio de Ciencia Innovacin y Universidades.
Education and qualifications:
Required:
- PhD Degree in Biotechnology or closely related fields centered in a fully Bioinformatics project
- Masters in Bioinformatics
- Bachelors degree in Sciences Biochemistry or Genetics
- Fluency in Catalan Spanish and English
Experience and knowledge:
Required:
- At least 4 to 5 years of experience working in the development of predictors of the impact of protein sequence variants on protein function (continuous prediction) in BRCA1/2 proteins
- Experience in the development of online tools for the graphical analysis of binary pathogenicity predictions
- Experience in the development of cost models (with reject and no reject options) for binary pathogenicity predictors
- Highlevel expertise in Python programming and Python data analysis tools (Jupyter Notebook Biopython Tabix Pandas Numpy Scipy ScikitLearn etc.
- Experience in bioinformatics analysis for biomedical/clinical applications of the following genomics experiments: Whole Exome Sequencing (WES) RNAseq scRNAseq ChIPseq microRNAseq and HiC (TAD location and analysis)
- Experience in web development (Django HTML5 CSS3 JavaScript etc.
- Experience in system administration of Mac and Ubuntu computers NAS storage etc.
Desired:
- Experience and good knowledge of standard bioinformatics tools (sequence comparison multiple sequence alignments structure analysis etc.
Main responsibilities and duties:
- Develop AI/ML models for identifying pathogenic and benign variants and processing single cell experiments looking for the cell of origin in Breast Cancer tumors.
- Take the lead in our research in the development of interpretable pathogenicity predictors based on RiskSLIM FasterRisk and GODST technology.
- Take the lead in our research in the development and web programming of our graphical representations for the interpretation of pathogenicity predictions.
- Active implementation and refinement whenever required of the cost models of our group.
- Manage our collaboration with the Oncogenetics group (VHIO) and the Immunogenetics Area (VHIR) at the Vall dHebron Hospital.
- Any other work required for ongoing or new research: analysis of epigenetic/epigenomics data of RNAseq experiments (bulk and singlecell) of WES etc.; structural analyses of protein systems; etc.
- All aspects related to the management of our computer systems from backups to updates particularly those associated to the research project.
Labour conditions:
- Fulltime position: 40h/week
- Starting date: April 1st 2025
- Gross annual salary: Remuneration will depend on experience and skills
- Contract: Technical and scientific activities contract linked to the project activities
What can we offer
- Incorporation to Vall dHebron Research Institute (VHIR) a public sector institution that promotes and develops the biomedical research innovation and teaching at Vall dHebron University Hospital (HUVH) the biggest hospital of Barcelona and the largest of Catalan Institute of Health (ICS).
- A scientific environment of excellence highly dynamic where highend biomedical projects are continuously developed.
- Continuous learning and a wide range of responsibilities within a stimulating work environment.
- Individual training opportunities.
- Flexible working hours.
- 23 days of holidays 9 personal days.
- Flexible Remuneration Program (including dining checks health insurance transportation and more)
- Corporate Benefits: platform through which you can obtain significant discounts on travel culture technology gastronomy sports... among many others.
- Healthy Offering: choose from a variety of wellbeing focused activities to be the healthiest you.
Deadline to apply:
VHIR embraces Equality and Diversity. As reflected in our values we work toward ensuring inclusion and equal opportunity in recruitment hiring training and management for all staff within the organization regardless of gender civil status family status sexual orientation gender identity and expression religion age functional diversity or ethnicity.
Employment Type
Full Time
Key Skills
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