Postdoctoral Researcher
Postdoctoral Researcher
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Job Description
Union: Non-Union
Number of vacancies: 1
Site: MaRS Centre 101 College Street Princess Margaret Research Tower Toronto Ontario Canada M5G 1L7
Department: Research
Reports to: Dr. Trevor Pugh Dr. Suzanne Trudel
Hours: 37.5 hours per week
Shifts: Day
Status: Temporary Full-time
Closing Date: August 15 2025
Position Summary
A postdoctoral fellowship is available in the laboratories of Dr. Trevor Pugh PhD FACMG and Dr. Suzanne Trudel MD at the Princess Margaret Cancer Centre / University Health Network in Toronto Canada. Located in the MaRS Centre in the heart of the downtown Discovery District we are an integral component of multiple translational genomics projects and platforms including the Cancer Genomics Program Tumour Immunotherapy Program Princess Margaret Genomics Centre. This position will support fellows wishing to lead the collaborative clinically-oriented myeloma genome analysis projects.
This position is an opportunity for scientifically creative computationally-inclined individuals with a strong cancer biology background to join our team focused on developing blood-based precision medicine approaches for Multiple Myeloma (MM). This project leverages whole-genome sequencing (WGS) of cell-free DNA (cfDNA) to enable non-invasive detection molecular characterization and longitudinal monitoring of MM. The successful candidate will lead efforts in integrating cfDNA WGS data with clinical and bone marrow biopsy data with the goal of reconstructing the MM genome identifying actionable mutations and developing novel biomarkers for minimal residual disease (MRD) and treatment resistance. This position offers the opportunity to work with cutting-edge sequencing technologies including 200X cfWGS and innovative computational tools in a translational research environment.
Candidates must have a PhD or MD with specialization in genetics molecular biology bioinformatics or computer science as well as hands-on experience in the use of Unix/Linux R/Matlab and statistical approaches to analyze and visualize genome-scale data sets. Preferred but not required are expertise in Python and Java programming web and database development industry software development practices (version control etc.) and expertise using tools for analyzing next-generation sequencing data such as the Genome Analysis Toolkit the Picard suite of tools and mutation detection algorithms. Candidates must be highly motivated possess excellent organizational problem-solving and communication skills (both verbal and written) and should have prior publications in cancer genomics immunology and/or biomedical journals.
Applicants should apply with a curriculum vitae and a cover letter in PDF format describing specific disease areas of interest to you how your past experience may complement training in computational cancer genomics and your future career goals. Applicants will be expected to apply for UHNs Canada Leads initiative to support this opportunity. A link to an active github repository showing past work would be viewed favourably.
Duties
- Will lead efforts in integrating cfDNA WGS data with clinical and bone marrow biopsy data with the goal of reconstructing the MM genome identifying actionable mutations and developing novel biomarkers for minimal residual disease (MRD) and treatment resistance.
- Work with cutting-edge sequencing technologies including 200X cfWGS and innovative computational tools in a translational research environment.
Qualifications :
- Ph.D. must be obtained within the previous 5 years in a related field
- Background in oncology/immunology genomics bioinformatics
- Experience in WGS WGTS scRNASeq data analysis
- Experience in Python Linux R and MatLab
- Applies fundamental knowledge of research principles theories and concepts
- Contributes to the development of new principles and concepts
- Keeps abreast of scientific developments
Additional Information :
Why join UHN
In addition to working alongside some of the most talented and inspiring healthcare professionals in the world UHN offers a wide range of benefits programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor allowing you to find value where it matters most to you now and throughout your career at UHN.
- Competitive offer packages
- Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP access to Transit and UHN shuttle service
- A flexible work environment
- Opportunities for development and promotions within a large organization
- Additional perks (multiple corporate discounts including: travel restaurants parking phone plans auto insurance discounts on-site gyms etc.)
Current UHN employees must have successfully completed their probationary period have a good employee record along with satisfactory attendance in accordance with UHNs attendance management program to be eligible for consideration.
All applications must be submitted before the posting close date.
UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.
Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading inaccurate or incorrect UHN reserves the right to discontinue with the consideration of their application.
UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.
We thank all applicants for their interest however only those selected for further consideration will be contacted.
Remote Work :
No
Employment Type :
Contract
Employment Type
Contract
