Senior Principal Scientist QSP Modelling

Are you passionate about advancing clinical drug development through cutting-edge quantitative systems pharmacology modelling

We are seeking a highly motivated and innovative QSP modelling expert to join our PBPK/QSP team within the Global Clinical Pharmacology - Pharmacometrics group. As a key member of multidisciplinary project teams you will develop implement and apply state-of-the-art mechanistic models to inform evidence-based decision making in clinical drug development. You will collaborate with different stakeholders within and outside of the CPS department.

Ready to shape the future of clinical pharmacology Apply now and be part of our journey!

This position can be performed in a hybrid format in Germany (Ingelheim or Biberach). It also be filled in the US (Ridgefield) Japan (Kobe) and China (Shanghai). For US Japan and China please apply on separate job postings.

• In your new role you will lead and execute clinical Quantitative Systems Pharmacology (QSP) modelling projects within multidisciplinary systems pharmacology pharmacometrics and drug development teams driving model-informed decision making across development programs.
• Additionally you will develop qualify apply and communicate fit-for-purpose QSP models that integrate non-clinical translational biomarker and clinical data to address critical scientific and development questions.
• You will also translate biological and pharmacological knowledge into quantitative model structures assumptions and simulations generating actionable insights while clearly communicating model limitations uncertainties and their potential impact.
• Furthermore you will define and drive QSP modelling strategies aligned with project objectives delivering scientifically robust analyses and interpretations to support clinical development decisions.
• You will provide independent advice on complex mechanistic modelling challenges and represent QSP expertise in cross-functional scientific technical and strategic discussions.
• Beyond this you will provide scientific leadership and guidance throughout model development qualification application and communication activities while fostering collaboration across internal teams and external partners.
• Finally you will drive innovation standardization and digitalization in mechanistic modelling and simulation by evaluating developing and implementing novel methodologies tools and technologies while overseeing external modelling activities to ensure scientific excellence and strategic alignment.

• PhD or equivalent advanced degree in systems pharmacology pharmacometrics clinical pharmacology computational biology bioengineering mathematics or a related quantitative field
• Several years of hands-on professional experience in QSP modelling in the pharmaceutical industry regulatory authorities or relevant academic research
• In-depth knowledge of mechanistic modelling in clinical drug development including model development calibration qualification simulation sensitivity analysis and interpretation of results
• Experience with R and/or relevant QSP modelling platforms such as MATLAB/SimBiology Julia OSP Suite or comparable tools; experience with statistical methods for analysis of nonclinical and clinical data is beneficial
• Strong ability to communicate complex modelling concepts assumptions uncertainties and decision impact clearly to multidisciplinary audiences
• Proven collaboration skills in international multidisciplinary teams and ability to interact effectively with internal and external stakeholders including experts CROs vendors and leadership teams
• Fluent in written and spoken English

As part of our commitment to transparency and fairness salary information will be shared during the recruitment process. We also offer a comprehensive benefits and wellbeing package.

Applications from persons with severe disabilities are warmly cases of equal qualifications such applicants will be given preferential consideration in the selection process.

If you have any questions about the job posting or process - please contact our HR Direct Team Tel: 49 (0) 6132 77-3330 or via mail:

Recruitment process:
Step 1: Online application - The job posting is presumably online until Sept 30 2026. We reserve the right to take the posting offline beforehand. Applications up to Sept 11 2026 are guaranteed to be considered.
Step 2: Virtual meeting in the period from mid-September till early October
Step 3: On-site interviews beginning of late October