Research Technician (Osterman Group – Metabolism-driven immunity)

EMBL Hamburg / CSSB

The European Molecular Biology Laboratory (EMBL) is Europes flagship life sciences organization with more than 110 independent research groups across Heidelberg Hamburg Grenoble Rome Barcelona and Cambridge. EMBL performs fundamental research in molecular biology develops advanced technologies trains scientists at all levels and provides cutting-edge services to the scientific community.

We are seeking a Research Technician with strong experimental expertise in structural biology and biochemistry to join the Osterman Group at EMBL Hamburg.

Our group investigates how metabolism shapes immunity with a focus on phagebacteria conflict systems enzymatic counter-defense mechanisms and metabolite-driven molecular arms races including NAD-centered pathways and phage-encoded metabolic innovations.

The successful candidate will contribute to ongoing structural and biochemical projects and is expected to take ownership of technically demanding experimental workflows. Depending on experience there is scope to develop independent sub-projects within the groups research framework.

Your role

• Execution and optimization of protein production pipelines including expression system selection purification strategy design and quality control.

• Support and development of biochemical and enzymatic assays including kinetic and functional characterization of proteins.

• Support of molecular biology and microbiology experiments relevant to protein function and pathway reconstitution.

• Participating in lab organization and management including ordering inventory and general maintenance of laboratory infrastructure

• Contributing to collaborative projects and depending on experience developing independent experimental sub-projects.

You have

• A Diploma or Masters degree in Biochemistry Structural Biology Molecular Biology Biophysics or a closely related field
  (PhD is an advantage; salary will reflect experience level).

• Strong hands-on experience in protein expression and purification including multi-step purification strategies and purity/quality assessment.

• Demonstrated experience with biochemical characterization of proteins ideally including enzymatic assays and mechanistic analysis.

• Solid understanding of protein biochemistry and structurefunction relationships.

• Ability to work independently on complex experimental tasks while contributing effectively to collaborative projects.

• Strong motivation and scientific curiosity in molecular mechanisms of enzymes and protein systems.

• Proficiency in English (spoken and written).

You may also have

• Experience in protein engineering or construct optimization.

• Practical experience in structural biology sample preparation with exposure to at least one of the following:

  • X-ray crystallography workflows

  • Cryo-EM sample preparation and grid screening

• Experience with reconstitution of enzymatic pathways in vitro.

• Interest in phage biology metabolic immunity or enzyme discovery.

We offer

• A highly interdisciplinary environment at EMBL Hamburg / CSSB integrating structural biology biochemistry and microbiology.

• Access to state-of-the-art infrastructure for X-ray crystallography cryo-EM protein biochemistry and microbial systems.

• Close interaction with international researchers working at the forefront of molecular mechanisms in hostpathogen systems.

• Opportunity to contribute to mechanistically driven discovery projects at the interface of metabolism and immunity.

• Possibility to develop technically independent research directions within ongoing projects.

Contract length: 5 years

Salary: Grade 5 (salary starting from EUR 4.14792 after tax and before 1299% EMBL social security deductions plus other paid benefits)

Why join us

EMBL is curiosity-driven community-oriented and international. As an inclusive equal opportunity employer we believe that diversity enables us to collaborate more effectively and be innovative in our approaches. We are therefore committed to creating an inclusive and flexible culture - one where everyone can realise their full potential and make a positive contribution to our organisation.

We encourage applications from individuals who can complement our existing team we believe that success is built on having teams whose backgrounds and personal experiences reflect the diversity of the populations that our science serves. We actively encourage applications from all genders and cultures ethnic groups and all demographics to help us avoid perpetuating biases and oversights at this transformational point in our people strategy.

Enjoy lots of benefits:

• Financial incentives:Salary free of income tax Monthly family child and non-resident allowances annual salary review pension scheme death benefit long-term care accident-at-work and unemployment insurances

• Flexible working arrangements

• Private medical insurancefor you and your immediate family (including all prescriptions and generous dental & optical cover)

• Generous time off:30 days annual leave per year in addition to public holidays

• Relocation packageincluding installation grant (if applicable)

• Campus life:Free shuttle bus (Heidelberg) library subsidised on-site cafeteria casual dress code extensive sports and social club activities (on campus and remotely)

• Family benefits: Kindergarten (Heidelberg) 10 days of child sick leave generous paid maternity/parental leave and monthly family & child allowances

• Benefits for international newcomers:Visa exemption education grant for private schooling financial support to travel back to your home country every second year and a monthly non-resident allowance.

• For detailed information please visit our employee benefits page here

What else you need to know

• International applicants: We recruit internationally and successful candidates are offered visa exemptions. Visit our International Applicants page to find out more.

• EMBL is a signatory of DORA. Find out how we apply DORA principles to our recruitment and performance assessment processes here.

• Diversity and inclusion: At EMBL we believe that diverse teams drive innovation and scientific excellence. We encourage applications from candidates of all genders identities nationalities and/or any other diverse backgrounds.

• How to apply: To apply please submit a cover letter and a CV through our online system. Applications will close at 23:59 CET on the date shown below. We aim to provide a response within two weeks after the closing date.

Closing Date