PhD Student (mfd)

TheDFG-funded Research Training Group (RTG) 3095Protective and pathogenic antibody responses at barrier organsis a collaborative doctoral programme jointly organized by theUniversity of LübeckandKiel University two modern and research-intensive universities with strong profiles in medicine molecular biology and the life sciences. Their study programmes have consistently achievedtop positions in the CHE Ranking the most comprehensive evaluation of study programmes at German universities.

Immunological barrier organs such as theskin intestine and lungsare continuously exposed to commensal microorganisms pathogens and environmental allergens. As a result infections as well as allergic and autoinflammatory disorders at these mucosal interfaces are frequent and represent asignificant burden to public health. Antibody-mediated immune responses play acentral rolein maintaining homeostasis at these sites: they contribute to thecontrol of pathogen invasion theregulation of gut microbiota and theinitiation and modulation of allergic reactions while also exerting regulatory functions that candownregulate inflammation.

The overarching goal of RTG 3095 is to elucidate themechanisms by which B cell responses are initiated maintained and contribute to either immunoprotection or immunopathogenesisat these immunological barrier sites. To achieve this the programme employsstate-of-the-art experimental approaches includingsingle-cell sequencingspatial transcriptomics and advanced molecular and immunological techniques. Doctoral researchers will benefit from astructured 4-year training programmethat integrates cutting-edge research with comprehensive training opportunities.

Start in our team

Within this framework the subproject P10 Diet-dependent metabolic regulatory and mitochondrial genomic states of B cell memoryled byProf. Patrick Maschmeyerat theInstitute for Systemic Inflammation Research (ISEF) University of Lübeck is seeking a PhD Candidate to start on November 1 2026. The position is initially limited until July 31 2030.

What we offer:

• The salary will be based on the German E13 TV-L scale if terms and conditions under collective bargaining law are fulfilled
• Part-time employment currently 25 hours/week
• Participation in the structured qualification programme of RTG 3095 including workshops courses and summer schoolsin state-of-the-art immunology related research.
• A highly stimulating research environment with access tostate-of-the-art technologiessuch as spectral flow cytometry and single-cell multi-omics
• Excellent opportunities for scientific networking and qualification in cutting-edge immunological research

Your tasks:

• Conducting a doctoral research project within P10 focusing on how high-fat diet and obesity shape allergic responses mitochondrial genome variation and the gene regulatory and metabolic programs underlying B cell memory formation
• Acquisition and analysis of single-cell multi-omics datasets derived from preclinical in vivo models
• Active participation in the scientific programme of the RTGs graduate training activities
• Presentation and discussion of research findings within the research consortium

Your profile:

• AMasters degree (or equivalent)in thelife sciencesor a related discipline fulfilling the formal requirements for enrolment as a doctoral candidate at the University of Lübeck
• Excellent command of English
• Experience withmouse modelsflow cytometry andmolecular and cellular biology techniques as well as knowledge ofGerman are advantageous
• Motivation to applybioinformatics approachesto the analysis of single-cell genomics datasets (e.g. scRNA-seq scATAC-seq); experience withRor comparable statistical software is desirable
• Strong motivation to contribute your own ideas to a dynamic interactive research team and an independent structured and collaborative working style

We look forward to receiving your application by October 14 2026 quoting reference number 29293.

Please include the following documents with your application:Amotivation letter (maximum one page)Acurriculum vitae (including a list of publications if applicable) Certificates and transcripts of your previous university degrees (BSc/MSc including transcripts of records)at leastone letter of recommendation Names andemail addresses of twopotential references.

Among the written applications suitable candidates will be invited for interviews in October 2026.

For further information please contact: Prof. Patrick MaschmeyerISEF Lübeck Maschmeyer Lab Email: