Senior Scientist, Cellular & Translational Sciences, OneLab

Title:

Senior Scientist Cellular & Translational Sciences OneLab

Company:

Ipsen Innovation (SAS)

About Ipsen:

Ipsen is a mid-sized global biopharmaceutical company with a focus on transformative medicines in three therapeutic areas: Oncology Rare Disease and Neuroscience. Supported by nearly 100 years of development experience with global hubs in the U.S. France and the U.K we tackle areas of high unmet medical need through research and innovation.

Our passionate teams in more than 40 countries are focused on what matters and endeavor every day to bring medicines to patients in 88 countries. We build a workplace that champions human-centric leadership and fosters a culture of collaboration excellence and impact. At Ipsen every individual is empowered to be their true selves grow and thrive alongside the companys success. Join us on our journey towards sustainable growth creating real impact on patients and society!

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Job Description:

WHAT - Summary & Purpose of the Position

The Senior Scientist Cellular & Translational Sciences OneLab is a senior laboratory-based scientific leader responsible for advancing Ipsens R&D portfolio across therapeutic areas including Oncology Rare Diseases and Neuroscience through the development and application of cutting-edge cellular characterization functional and translational approaches.

The role provides scientific and operational leadership for preclinical and translational laboratory activities with particular expertise in high-dimensional flow cytometry cellular profiling and functional cellular assays. The position drives the generation of decision-enabling data supporting target validation candidate selection mechanism-of-action and pharmacodynamic studies biomarker discovery and clinical translation.

As a recognized subject matter expert in flow cytometry and cellular profiling the individual will lead the development of innovative experimental strategies applicable across therapeutic areas oversee laboratory capabilities manage scientists and/or postdoctoral researchers and contribute to portfolio decisions through deep scientific expertise and cross-functional collaboration.

WHAT - Main Responsibilities & Technical Competencies

Scientific Leadership

Provide scientific leadership for cellular and translational laboratory activities across multiple research and development programs and therapeutic areas including Oncology Rare Diseases and Neuroscience.

Generate mechanistic and translational scientific insights that inform drug discovery candidate progression and development strategies.

Partner with project and cross-functional teams to translate biological questions into robust experimental strategies and decision-enabling data.

Identify evaluate and implement emerging technologies and innovative approaches relevant to cellular biology translational science and drug development.

Contribute scientific expertise to portfolio and project decisions across different modalities mechanisms of action and disease areas.

Advanced Flow Cytometry & Cellular Profiling Expertise

Act as Ipsens laboratory subject matter expert for advanced flow cytometry and cellular profiling applications across therapeutic areas.

Design implement and continuously improve complex multi-parameter and spectral flow cytometry panels.

Develop cellular profiling strategies to characterize disease-relevant cell populations cellular phenotypes target expression pathway modulation and pharmacological responses.

Develop and qualify robust assays enabling characterization of cell identity activation state functional responses target engagement pharmacodynamic effects and mechanisms of action.

Establish best practices for assay design panel optimization data quality reproducibility and quantitative data analysis.

Drive innovation in single-cell high-content and multimodal cellular profiling technologies.

Provide scientific guidance on the interpretation and biological relevance of complex cellular datasets.

Establish and maintain efficient technology-transfer processes for internally developed assays to external partners and CROs ensuring reproducibility quality and compliance.

Laboratory Leadership

Lead laboratory activities for advanced flow cytometry supporting research objectives.

Ensure scientific excellence data integrity and compliance with laboratory standards.

Oversee study design execution data analysis and reporting of pharmacological reports.

Develop laboratory capabilities and contribute to strategic investment and technology roadmaps.

Manage external laboratories and CRO collaborations when required.

People Management

Directly manage laboratory scientist(s) and/or postdoctoral researcher(s).

Establish objectives priorities and development plans for team members.

Coach and mentor scientists to foster scientific excellence and innovation.

Create a collaborative and high-performing laboratory environment.

HOW - Behavioural Competencies Required

Cultivate Innovation

Questions status-quo and adopt new approaches;

Has vision bring ideas and possibilities and turn it into actions;

Thinks outside the box reframes problems in different lights;

Encourages/considers/integrates different perspectives/ideas

Innovation is central to the position rather than incidental. The role is expected to identify emerging technologies develop innovative immunoprofiling strategies and actively advance single-cell and high-content approaches. This makes the ability to challenge existing approaches and translate new ideas into action especially important for future emerging technologies and innovative approaches relevant to immuno-oncology and translational science.

Drive innovation in single-cell and high-content immune profiling technologies.

As a recognized subject matter expert in flow cytometry the individual will lead the development of innovative immunoprofiling strategies oversee laboratory capabilities manage a team of scientists and/or postdoctoral researchers and contribute to portfolio decisions through deep scientific expertise and cross-functional collaboration.

Excellence in execution

Approaches priority setting and setting the stage through the lens of execution;

Establishes clarity about the goals accountabilities timelines and next steps; can identify/spot opportunities for real impact on patient and society;

Able to be focused and performance-driven with clear KPIs

Plans and aligns effectively (steps resources timelines etc.);

Displays a commitment to best practice sharing and setting

Promotes single point of role combines scientific leadership with operational laboratory responsibility. Success requires converting scientific strategy into robust assays and studies maintaining quality and reproducibility and overseeing execution analysis and reporting. These responsibilities align very closely with disciplined planning prioritisation clarity and best-practice execution. Establish best practices for assay design panel optimization data quality reproducibility and analysis.

Ensure scientific excellence data integrity and compliance with laboratory standards.

Oversee study design execution data analysis and reporting of pharmacological reports.

Develops/ coaches Talent

Able to identify and align career goals and blend organizational objectives into a cohesive development plan for self and team;

Able to coach

Provides structured actionable regular and directional feedback and acts as a coach to empower people to own their own growth/development;

Prepares their own succession plans;

Displays a radically human-centered mindset; puts people first; focuses on doing good;

Demonstrates ability to build team effectiveness. People development is an explicit part of this senior scientific leadership position. The individual is expected not simply to supervise scientists but to establish development plans coach and mentor them and build an effective laboratory team. The competency therefore directly supports a significant continuing responsibility of the role. Directly manage laboratory scientist(s) and/or postdoctoral researcher(s).

Establish objectives priorities and development plans for team members.

Coach and mentor scientists to foster scientific excellence and innovation.

Collaborates Collaborates and communicates without boundaries continuously removes organizational barriers;

Focuses on continuous improvement; integrates and leverages key learnings showcases resourcefulness learning/experimenting at scale demonstrates strong entrepreneurial behaviors and mindset. The position must operate beyond its immediate laboratory. Its scientific expertise feeds portfolio decisions it works cross-functionally and it manages relationships with external laboratories and CROs. Collaboration is therefore important for converting specialist laboratory expertise into broader R&D impact. As a recognized subject matter expert in flow cytometry the individual will lead the development of innovative immunoprofiling strategies oversee laboratory capabilities manage a team of scientists and/or postdoctoral researchers and contribute to portfolio decisions through deep scientific expertise and cross-functional collaboration.

Establish and maintain efficient technology transfer processes for internally developed assays to external partners and CROs ensuring reproducibility quality and compliance.

Manage external laboratories and CRO collaborations when required.

Manage Complexity Identifies contradictory information/demands/inputs to effectively solve problems;

Develops and evaluates alternative scenario and solutions;

Able to identify what truly matters and ruthlessly focus/ prioritize on making decisions with real impact. The scientific remit requires interpretation of complex biological and high-dimensional flow-cytometry information and using that evidence to inform consequential development decisions. Managing complexity is therefore particularly relevant to translating technically sophisticated experiments into clear scientific guidance and portfolio decisions. The position drives the generation of decision-enabling data supporting target validation candidate selection mechanism-of-action studies biomarker discovery and clinical translation.

Design implement and continuously improve complex multi-parameter and spectral flow cytometry panels.

Provide scientific guidance on flow cytometry data interpretation and biological significance.

HOW - Knowledge & Experience

Knowledge & Experience (essential):

Extensive experience in advanced flow cytometry and cellular biology with recognized expertise in pharmaceutical biotechnology or leading academic research environments.

Demonstrated experience developing and applying complex multicolor and/or spectral flow cytometry assays.

Strong understanding of cellular biology pharmacology disease mechanisms and translational science.

Demonstrated ability to apply cellular technologies to answer mechanistic and drug-development questions.

Proven track record of leading translational or preclinical research activities supporting drug discovery and/or development.

Experience developing robust reproducible and decision-enabling cellular assays.

Experience managing laboratory scientists and/or postdoctoral researchers.

Strong scientific communication and publication track record.

Experience working within multidisciplinary drug-development teams.

Knowledge & Experience (preferred):

Experience applying cellular and translational approaches within one or more therapeutic areas including Oncology Rare Diseases and/or Neuroscience.

Experience with clinical biomarker development and pharmacodynamic or cellular biomarker assessment.

Experience with single-cell technologies high-content imaging spatial biology and/or other advanced cellular profiling approaches.

Experience supporting IND/CTA-enabling or clinical development activities.

Experience with human primary cells disease-relevant cellular models and/or translational sample analysis.

Experience managing external collaborations and CROs.

Excellent written and verbal communication skills in French and English

Ability to anticipate and coordinate multiple activities simultaneously.

Eagerness and willingness to learn and grow.

Education / Certifications (essential):

Master of Science degree or PhD plus a minimum of 5 years of experience in biotech and/or pharmaceutical companies.

Flow cytometry Postgraduate University Diploma

Language(s):

Fluent in French and English

#LI-MM1 #LI-hybrid

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