R&D Intern HFX

TISSIUM is a mission-driven medical device company founded in 2013 headquartered in Paris with a production facility in Roncq (near Lille) and an office in Boston. We are dedicated to creating a new era of body repair by leveraging our biopolymer platform to develop innovative solutions in surgery for a positive impact on patients lives.

TISSIUMs technology is based on research and intellectual property from the laboratories of Professor Robert Langer (MIT) and Professor Jeffrey M. Karp (Brigham and Womens Hospital) who co-founded the company with Christophe Bancel (CEO) and Maria Pereira (Deputy CEO & Chief Innovation Officer).

We develop polymers for atraumatic tissue repair. Today they are used for sutureless nerve repair hernia repair and cardiovascular sealing.

Since our inception we have raised a total of 170 million euros including 50 million euros in our latest round (April 2023) to finance the commercialization of our first products.

You will join a real development project at a decisive moment. The device is a minimally invasive atraumatic fixation method for gastrointestinal surgery and it is entering its pre-verification and validation (pre-V&V) phase.

Over your 6 months the team will finalize the prototype develop and validate the test methods that will assess device performance in V&V and produce the documentation needed to reach Design Freeze. Working alongside experienced engineers you will contribute to each of these steps and see first-hand how a medical device moves towards V&V.

• Testing strategy: take part in discussions on how the device will be tested in V&V and support the team in developing and validating test methods.

• Lab and surgeon testing: help carry out and document bench tests in TISSIUMs laboratory (mechanical testing fixation performance on biological tissues) and participate in simulated-use tests with surgeons on human anatomical models and/or animal models.

• Data analysis: organize and analyze experimental results and help prepare technical reports and presentations shared in team meetings.

• Documentation: contribute to drafting study plans study reports SOPs work instructions and other Design History File (DHF) documents.

• Literature and data review: gather and summarize relevant insights from internal company data and the scientific literature.

• Quality and regulations: learn and apply company procedures the Quality Management System and medical device regulations.

You will be part of the Innovation & New Concepts team within TISSIUMs R&D Department reporting to the R&D Manager leading the project. Day to day you will:

• Work with R&D colleagues to learn the specifics of our products (polymer light-activation devices).

• Collaborate with the teams supporting device development such as Quality and Advanced Manufacturing Engineering.

• Meet surgeons to gather their feedback on device handling and performance.

• You are an engineering or Masters student in biomedical engineering or a related field available for a 6-month internship in Paris starting JanuaryFebruary 2027.

• You have hands-on experience with laboratory testing data analysis and reporting (projects previous internships or research work all count).

• You are fluent in English written and spoken: English is TISSIUMs official working language.

• You are willing to take part in animal experimentation and/or handle animal tissues.

• Experience with CAD design and 3D printing.

• Organized and detail-oriented.

• Resourceful and proactive.

• Can-do attitude with the ability to prioritize the most critical activities and adjust priorities as needed.

• Ability to work effectively both independently and as part of a team fostering collaboration and cooperation.

• Strong communication skills with the ability to convey technical information to different audiences.

• Contribute to a medical device development project.

• Gain exposure to medical device development: test methods Design History File documentation Quality Management System and applicable regulations.

• Interact with surgeons to gather feedback on device handling and performance.

• Work across teams and settings: R&D Quality and Advanced Manufacturing Engineering in TISSIUMs laboratory and at external CROs.

• Join a mission-driven company whose technology is based on research from the laboratories of Professor Robert Langer (MIT) and Professor Jeffrey M. Karp (Brigham and Womens Hospital).

1. HR interview (30 min video): your motivation availability and internship agreement.

2. Interview with the R&D Manager (4560 min video): your lab experience a past project you are proud of and how you would approach the role

3. Team meeting (on site in Paris): meet the Innovation team and visit the lab.