CMC Engineer Intern – Polymer Development MFX

TISSIUM is a mission-driven medical device company founded in 2013 headquartered in Paris with a production facility in Roncq (near Lille) and an office in Boston. We are dedicated to creating a new era of body repair by leveraging our biopolymer platform to develop innovative solutions in surgery for a positive impact on patients lives.

TISSIUMs technology is based on research and intellectual property from the laboratories of Professor Robert Langer (MIT) and Professor Jeffrey M. Karp (Brigham and Womens Hospital) who co-founded the company with Christophe Bancel (CEO) and Maria Pereira (Deputy CEO & Chief Innovation Officer).

We develop polymers for atraumatic tissue repair. Today they are used for sutureless nerve repair hernia repair and cardiovascular sealing.

Since our inception we have raised a total of 170 million euros including 50 million euros in our latest round (April 2023) to finance the commercialization of our first products.

As part of your end-of-studies internship you will join Tissiums CMC (Chemistry Manufacturing & Controls) team in Paris for 6 months starting january/february reporting to a Senior CMC Engineer.

The CMC team develops the polymers at the heart of our medical devices. You will contribute to every stage of their development:

• deepening our understanding of their structure and physico-chemical properties

• designing and optimizing manufacturing processes

• running the studies that demonstrate their safety and performance

The internship includes a significant share of hands-on lab work alongside interactions with our external partners and subcontractors.

• Perform the experimental work supporting the development of Tissium polymers: chemical reactions purifications analytics performance testing

• Help design perform and follow key testing methods to support the safety and performance of our polymers

• Analyze your results and report on them

• Support the setup and management of process design and optimization activities through scale-up and transfer to production internally or with subcontractors

• Help plan and follow up on subcontracted activities: feasibility and optimization work production planning batch reviews

• Contribute to the design planning and follow-up of key verification and validation studies (e.g. stability studies in vitro degradation studies)

• Support the team in writing and reviewing CMC documentation for Tissium products

• Work in line with Tissiums Quality Management System and applicable regulatory requirements

• Final-year engineering student or equivalent with a background in chemistry process development and/or analytics

• First hands-on lab experience (internship or project): basic synthesis and purification techniques use of standard analytical equipment data analysis and reporting

• Professional proficiency in English written and spoken

• Knowledge of polymers and/or materials science

You are autonomous and well organized with strong planning and problem-solving skills. You approach technical challenges creatively and are comfortable understanding complex processes involving several partners. You are a team player and eager to learn.

• A hands-on end-to-end internship: from the lab bench to production and validation studies you will see the full development cycle of a medical-grade polymer

• Meaningful impact: our polymers are used for sutureless nerve repair hernia repair and cardiovascular sealing

• Real mentoring: day-to-day supervision by a senior engineer of the CMC team

• An international environment: 19 nationalities with teams in Paris Roncq and Boston

• Internship allowance and benefits: monthly amount meal vouchers transport reimbursement

• End-of-studies internship (internship agreement required)

• Duration: 6 months starting in january/february

• Location: Paris

1. HR video interview (30 min)

2. Video interview with the manager (1h)

3. On-site meeting with the team