Senior Scientist Process Development

Our client is a startup biotech company and located near Zurich Switzerland. The company develops novel biologics for a wide range of indications.

To strengthen the team we are looking for a versatile and experienced

Tasks

• Plan design and conduct experiments for process development studies with minimal supervision.
• Proactively research literature to identify potential substantial improvements and translate them into scientifically sound experimental plans.
• Use bioprocessing experience to identify critical process parameters that affect upstream performance.
• Explore and apply appropriate analytical tools to extend the metabolic understanding of the organism and fermentation processes.
• Perform routine bioreactor runs for protein production activities.
• Record data and results in lab notebooks perform data analysis and present data in lab and development team meetings.
• The laboratory activities include preparatory activities shake flask and bioreactor cell culture operations:
• media and buffer preparations according to standard operating procedures (SOPs) ensuring accurate measurements proper mixing and sterilization.
• prepare and set up bioreactors for cell culture including sterilization assembly and installation/calibration of sensors and probes.
• Setup shake flasks in shaker incubators for Preculture and perform shake flask trials.
• Monitor and maintain bioreactor conditions throughout the culture process including offline measurements such as Optical Density Cell counts Cell viability Glucose osmolality pH conductivity and other measurements on a routine basis.
• Perform additional cell culture operations such as preculture inoculation and harvesting. Harvesting includes centrifugation and sterile filtration.
• Follow all established SOPs and guidelines to ensure the integrity of cell cultures prevent contamination and maintain compliance.
• Manage inventory of cell culture reagents media components and other consumables to prevent shortages and ensure uninterrupted operations.
• Participate in training and development opportunities to stay current with industry best practices and emerging technologies.
• Provide subject matter expertise for processes and equipment and perform tech transfer to external labs and CDMOs. Support scaleup and largescale bioreactor runs at external manufacturing sites.
• Supervise a junior RA to support routine productions.

Requirements

You have a proven handson track record in biochemistry and protein analytics and/or have considerable relevant professional experience. If you are a selfsufficient flexible reliable and precise person meet the requirements listed below and are willing to bring projects to success we are looking forward to hearing from you!

• PhD or Masters degree in Cell Biology Biochemistry Biotechnology or a related field preferred.
• Minimum of 5 years ideally 7 years of relevant experience in a fermentation/ cell culture laboratory setting.
• Hands on experience in process development and good understanding of cell culture techniques aseptic procedures bioreactor operations.
• Proven ability to work independently and as part of a team.
• Previous experience with either microbial and/or mammalian cell culture required.
• Excellent organizational and time management skills.
• Meticulous attention to detail and a commitment to quality control.
• Ability to work in a fastpaced and demanding environment.
• Excellent verbal and written communication skills in English
• Good ITknowledge (Excel PowerPoint databases)
• Proactive and problemsolving attitude
• Selfmotivation and ability to work independently in a fastpace small company environment
• Excellent interpersonal and negotiation skills
• Team player collaborative attitude.

Benefits

The working place is easily accessible by public transportation and you will meet a friendly highly motivated and dynamic team.