Associate Scientist - DP formulation and manufacturing

ProQR Therapeutics

ProQR Therapeutics is a biotechnology company listed on NASDAQ with offices in Leiden the Netherlands and Cambridge Massachusetts USA. ProQR is focused on the development of life changing RNA therapies to meet the unmet need of individuals and families with common and rare diseases. A team of 150 enthusiastic ProQRians from all walks of life and more than 30 different nationalities is up to this challenge. We have the passion and commitment to make a difference in the lives of the communities we serve. Our proprietary Axiomer RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cells own editing machinery. Axiomer RNA editing technology harnesses ADAR (Adenosine Deaminase Acting on RNA) which is machinery present in all human cells to repair GtoA mutations modulate protein and enable protective mutation functions. Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable diseases.

Our Chemistry Manufacturing and Control (CMC) Department is currently looking for an (Associate) Scientist (Fulltime) with a passion for formulation developmentto join our team in Leiden. The CMC department has a central role within the ProQR Therapeutics organization and is responsible for developing manufacturing and characterizing oligonucleotides and therapeutic formulations for research clinical development and commercialization.

Location: Leiden NL (onsite)

The Role

The (Associate) Scientist will support the inhouse laboratory activities of the DP formulation & manufacturing team which is part of the CMC department.

The successful candidate is enthusiastic about bench work and will work closely with other researchers/scientists in an interdisciplinary team environment to progress activities related to the production of oligonucleotides which include:

• Formulation development and characterization
• Assessment of dosage forms (such as vials prefilled syringes)

• Writing of technical protocols and reports
• Execution of formulation experiments (including testing the Physicochemical characteristics and particle size analysis)
• Accountable for the planning of activities and delivery to meet project milestones
• Preparation or revision of standard operating procedures (SOPs)
• Identification and implementation of continuous improvement opportunities
• General lab activities such as equipment maintenance and inventory management

We expect our (Associate) Scientist to have:

• Ph.D. in pharmaceutical sciences or related discipline with 03 years of industry experience or Masters with at least 57 years of experience or at least 9 years of work experience and highly competent performance at a BSc level (HBO) or performing progressively advanced duties at the Associate Scientist level or the equivalent training/work experience
• Strong laboratory skills and a high degree of attention to detail
• A proven track record of publications and presentations
• Effective verbal and written communication skills in English
• Outstanding computer and mathematics skills and advanced science skills.
• Experience with sterile liquid drug product formulation
• Responsible with a proactive attitude who can work independently
• Being flexible analytical and wellorganized

Preferred:

• Experience in complex formulation (for intravenous and CNS delivery) and prefillable syringe/ cartridge design and manufacturing
• Experience in preparation of CMC regulatory documents for submission in support of clinical trials and MAA application
• Knowledge of GMP practices and pharmacopeial methods
• Experience of working with external CMOs
• Experience with oligonucleotides is a plus

Skills and competencies that are required for making the difference:

• Team player with a handson mentality
• Patientoriented attitude
• Being able to work in a fastpaced environment
• Strong project planning and management skills able to prioritize multiple tasks
• Being a nice person

ProQR as an employer

As an employer we are a true believer of the value of a workforce in which people from diverse backgrounds are encouraged to develop themselves personally and professionally. We believe that happy and energized people working well together in an environment in which they thrive will do phenomenal and awesome things.

We are committed to ensuring that no employee candidate or job applicant receives less favorable treatment on the grounds of race age disability pregnancy religion gender identity and expression sexual orientation marriage or civil partnership status. At ProQR we want to create an inclusive culture where everyone can be valued for who they are and in which individual differences and contributions in all forms are recognized and valued.

We offer an exciting and innovative working environment in a very committed organization with the following benefits:

• A competitive salary
• 8% holiday allowance
• 30 vacation days
• An annual performance bonus
• Stock options
• A premiumfree pension plan
• A commuting allowance
• A subsidized staff restaurant
• Unlimited (un)healthy snacks and drinks
• Employee events (boot camp Rebel Caf and other social events)

Do you think you can contribute to achieving our mission If so were looking forward to receiving your application by filling out our application form. Please apply as soon as possible if you are interested in this position. You can contact Silvia Catellani via if you have any questions.