Employer Active
We recently secured NIH funding for a project investigating heterotypic amyloid interactions as modulators of selective cellular vulnerability. Were looking for two experienced postdoctoral researchers with strong backgrounds in cell biology and biophysics both within a protein aggregation context.
Amyloid aggregates form in certain regions of the brain and not in others. We will investigate whether specific (heterotypic) interactions between the aggregationprone regions of amyloidforming proteins and the background proteome account for this. This hypothesis will be tested by performing a genomewide computational screen and then testing the candidate proteins first in cellular models and then in mice. Biophysical analyses will shine a light on the exact mechanism by which heterotypic interactions change amyloid formation.
The SWITCH Laboratory is a leader in the field of protein aggregation research related to human disease. We are an interdisciplinary workplace bringing together more than twentyfive researchers from different backgrounds such as bioinformatics biophysics chemistry and cell biology. SWITCH has a unique platform of technologies for studying protein aggregation including biophysical ultrastructural and cell biological instrumentations. You can read more about us on our website and be sure to check out our laboratory section to explore the fantastic infrastructure that SWITCH has to offer!
Together with the PIs of the Switch Lab you will be part of a team of post docs and technicians and will be a driving force for this project. You will be well supported on an administrative level allowing you to focus on the science both handson in the lab and analyzing data.
Position 1 Cellular biology of heterotypic amyloid interactions
Position 2 Biophysics of heterotypic amyloid interactions
Starting Date: as soon as possible
For more information contact Please complete the online application procedure and include a detailed CV including list of publications a motivation letter and the contact information of at least two referees.
Full Time