2 funded postdoc positions ERC project - de novo protein design high-throughput biophysics
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Job Description
Overview
Two postdoc positions are available at the Laboratory of Computational Protein Design in Brussels () and are funded by an ERC grant. The focus of the group is the de novo design of membrane proteins and nanopores for applications such as singlemolecule sensing. In that context this ERC project aims to (i) develop a new experimental platform for highthroughput characterization of the biophysical properties of natural and synthetic protein nanopores and (ii) leverage the generated data for the development of better computational design methods based on the Rosetta software and the latest generative deep learning software for protein design.
We are therefore looking for two profiles with interest in the design of membrane proteins:
Profile 1
Recent Ph.D. in experimental protein engineering/directed evolution.
Demonstrated experience in:
- Developing and using highthroughput assays.
- Library construction (mutagenesis oligo pools).
- Recombinant expression purification and characterization of proteins.
- Deep sequencing and analysis.
Experience with membrane proteins and/or cellfree expression will be regarded as a plus.
Profile 2
Recent Ph.D. in computational protein design or modelling.
Demonstrated experience in:
- Modelling/design of protein with Rosetta AlphaFold and/or deep learning.
- Deep sequencing data analysis and interpretation.
- Good understanding of (membrane) protein structure.
The two candidates will collaborate and should therefore have excellent verbal and written English communication to facilitate interdisciplinary work.
We offer
- Stateoftheart structural biology computing and protein engineering facilities
- Excellent training in academic technical and career skills.
- A stimulating and supportive international research environment.
- VIB provides competitive salary and benefits as well as participation in national social security healthcare and retirement plans.
- Starting date: April 2024
How to apply
Interested candidates should submit their candidacy through the VIB online application tool.
A complete application file (English) should contain the following documents:
- your cover/motivation letter stating career goals past experience and how these relate to the current position
- your CV
- contact information of 2 references
For further information and questions please send an email to Anastassia Vorobieva ().
Employment Type
Full Time
