Principal Scientist, Clinical Outcomes

Job Description:

We believe in bold ideas diverse perspectives and the drive to transform knowledge into impact. Here your curiosity fuels progress your voice shapes innovation and your ambition helps redefine whats possible within science and learning. We are a culture that obsesses over impact challenges and drives whats next to power infinite possibilities for our customers colleagues and society at large.

About the Role:

We are looking for a Principal Scientist to be the senior scientific voice across Wileys Clinical Outcome Assessment (COA) work part of our AI and Data Analytics organisation. The role exists to make sure that the science underpinning every instrument we work with is sound current and well-represented and that decisions across our business reflect the views of clinical authors and instrument developers. The role works closely with the medical societies and academic authors who originated these instruments supports their continued scientific development and represents Wiley credibly in the clinical outcomes community. It is an opportunity to do real scientific work alongside commercial product partnership and publishing colleagues and reports to the Senior Director Clinical Outcome Assessments.

Job Responsibilities

• Provide expert scientific assessment of instruments across the portfolio evaluating psychometric properties validation evidence and regulatory precedent in line with current measurement science.
• Work closely with the medical societies instrument authors and academic groups behind the instruments in our portfolio supporting their scientific work and acting as a senior point of contact for scientific questions.
• Support the continued scientific development of instruments alongside their authors and Scientific Affairs colleagues including evidence updates validation work and considered translation and adaptation programmes.
• Provide scientific guidance to colleagues across the business so that customer conversations product builds and partnership decisions all reflect sound clinical measurement principles.
• Represent Wiley as an active and credible participant in the clinical outcomes community including at ISOQOL ISPOR CPATH and other professional forums.
• Provide scientific input to clinical platform product development ensuring the platforms are built on sound clinical foundations and respect the integrity of the underlying instruments.

Required Qualifications

• Postgraduate degree (MSc PhD or equivalent) in clinical outcomes research psychometrics health economics and outcomes research (HEOR) epidemiology clinical psychology or a closely related discipline. Strong academic background combined with substantial practical experience in clinical measurement science is also acceptable.
• 5 years working with Clinical Outcome Assessments in a scientific regulatory or commercial context including roles in pharmaceutical clinical development CRO scientific affairs health outcomes consultancy academic research in psychometrics or patient-reported outcomes or regulatory science.
• Demonstrated ability to evaluate the psychometric properties and clinical utility of measurement instruments.
• Familiarity with the regulatory landscape for COAs including FDA Patient-Focused Drug Development guidance EMA qualification and ICH standards.
• Strong literature review and evidence synthesis skills.
• Familiarity with psychometric validation methodologies (classical test theory item response theory Rasch analysis).
• Ability to communicate complex scientific and psychometric concepts to both technical and non-technical audiences with credibility among clinical and academic peers.

Preferred Qualifications

• PhD in psychometrics HEOR or clinical outcomes research.
• Published research in COA-related fields.
• Experience working across multiple therapeutic areas.
• Track record of contributing to instrument development validation or regulatory submission ideally in collaboration with academic or society partners.
• Experience with systematic evidence review or meta-analysis.
• Familiarity with CDISC standards for COA data.
• Active engagement with ISOQOL ISPOR CPATH or equivalent professional communities.
• Familiarity with electronic COA implementation and the impact of mode of administration on measurement properties.
• Knowledge of AI-assisted evidence synthesis approaches.

We power infinite possibilities.

For more than 200 years weve transformed knowledge into discoveries that shape the world. Today our global team of innovators creators and experts is driving whats next in science education and publishingcreating impact that reaches everywhere.

Were not just observers of progress. Were the ones accelerating scientific breakthroughs advancing learning and sparking innovation that redefines entire fields and improves lives.

Here your talent matters. Your ideas have room to grow. And your work creates breakthroughs that can change everything.

Wiley is an equal opportunity/affirmative action employer. We evaluate all qualified applicants and treat all qualified applicants and employees without regard to race color religion sex sexual orientation gender identity or expression national origin disability protected veteran status genetic information or based on any individuals status in any group or class protected by applicable federal state or local laws. Wiley is also committed to providing reasonable accommodation to applicants and employees with disabilities. Applicants who require accommodation to participate in the job application process may contact for assistance.

We are proud that our workplace promotes continual learning and internal mobility. Our values support courageous teammates needle movers and learning champions all while striving to support the health and well-being of all employees. We offer meeting-free Friday afternoons allowing more time for heads down work and professional development and through a robust body of employee programing we facilitate a wide range of opportunities to foster community learn and grow.

We are committed to fair transparent pay and we strive to provide competitive compensation in addition to a comprehensive benefits package. The range below represents Wileys good faith and reasonable estimate of the base pay for this role at the time of posting roles either in the United Kingdom Canada or USA. It is anticipated that most qualified candidates will fall within the range however the ultimate salary offered for this role may be higher or lower and will be set based on a variety of non-discriminatory factors including but not limited to geographic location skills and competencies.

When applying please attach your resume/CV to be considered.

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