Scientist

Join AstraZenecas InVivoDiscovery Platforms group within the Biologics Engineering department where we are pushing the boundaries of science to deliver life-changing medicines. Our passion for discovery drives us to explore novel therapeutic approaches across various diseases including Oncology Respiratory Cardiovascular and Infectious diseases. As part of our collaborative network you will have the opportunity to engage with new and exciting technologies that are transforming patient care.

Accountabilities:

As a key member of the team you will design and executein vivostudies interpret pharmacokinetic (PK) data and develop and qualify PK assays to supportdiscoveryprogramsand novel platform technologies. You will evaluate panels of lead candidatesin vivo deliver high-quality PK datasets and collaborate closely withcrossfunctionalpartners to inform data-driven decision making across programs. Your strong work ethic exceptional organization and clear communication will be critical to delivering impact and advancing our portfolio.

In this role you will:

• Complete wet-lab experiments (80%) and data analysis(20%).

• Design and executeinvivoPK studies across relevant species; coordinateanimaldosing sampling andlogistics; ensure data integrity and compliance with internal SOPs and applicable guidelines.

• Developqualify and wherevalidatePK bioanalytical assaysfitfor purpose across discovery and regulated contexts.

• Perform PK sample analysis troubleshoot assays and deliverhighqualitydatasets within agreed timelines; ensureappropriate controlsand documentation for traceability.

• Collaborate withinvitroinvivo and bioanalysis scientists to build research plans and align on study designs; present data and recommendations to project teams and department leadership.

• Identifyopportunities to streamline workflows implement best practices and adoptnew technologiesto improve throughput quality and decision speed.

• Assistwith cell culture including routine maintenance and expansion.

• Work within a matrixed environment across multiple groups.

Essential Skills/Experience:

Educational requirements:

BS (5 years) or MS (2 years) withhandsonexperience in animal handling bioanalysis pharmaceutical sciences or a closely related discipline.

Required skills:

• Strong background in immunochemical and /or cell-based assays including experience with cell culture techniqueshigh throughput flow cytometryligand-bindingELISA MSDas well as other novel bioanalytical techniques and platforms.

• InVivoPK Expertise:Handsonexperience planning and executing PKinvivostudies includinganimaldosing sampling and PK sample handling; understanding of species selection exposure targets and PKprinciples.

• Bioanalytical Skills: Practical experience with PK assay development and qualification (e.g.ligandbindingassays such as ELISA/ECL); familiarity with regulated bioanalysis expectations.

• Data and Tools:Proficiencywith PK data processing.

• Communication and Collaboration: Strong written and verbal communication skills;demonstratedability to present PK/bioanalytical results to multidisciplinary teams.

• Organization and Execution: Proven ability to manage multiple studies in parallel meet timelines andmaintainmeticulous documentationin accordance withSOPs and quality standards.

Desirable Skills/Experience:

• Laboratory experience withGxPregulations documentation regulatory guidance and regulatory submission.

• Understanding of immunogenicity assessments and their impact on PK; experience with biologics modalities (e.g.mAbsbispecifics ADCs peptides nucleicacidbasedtherapies).

• Familiarity with spreadsheet word processing and graphical computer programs (e.g.Excel Word GraphPad Prism etc.)andexperience with electronic notebook keeping and data entry usingGenedataBiologics

AstraZeneca is where bold thinking meets relentless curiosity. Our ambition to transform outcomes across oncology respiratory and immunology (R&I) cardiovascular renal and metabolism (CVRM) and infectious disease drives us to harness advanced science and technology. Withhighqualitymolecules across multiple indications and every stage of development we make decisivepatientfirstchoices that accelerate impact. Our collaborative ecosystembrings together diverseexpertiseto tackle some of the most challenging diseases. Here you can build a fulfilling career focused on improving the lives of millions of patients worldwide.

Ready to shapewhatsnext Apply today to join our team.

The annual base pay (or hourly rate of compensation) for this position ranges from $92252 to $ positions offer eligibility for various incentivesan opportunity to receive short-term incentive bonuses equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs paid time off (i.e. vacation holiday and leaves) as well as health dental and vision coverage in accordance with the terms of the applicable plans.