Scientist

Do you have a passion forScience Would you like to apply yourexpertisetoimpacta company that followsthe scienceand turns ideas into life changing medicines Then AstraZeneca might be the one for you!

At AstraZeneca we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial thinkingbigand working together to make the impossible a reality. If you are swift to action confident to lead willing to collaborate and curious about what science can do thenyoureour kind of person.

About AstraZeneca in Gaithersburg MD:

Our Gaithersburg Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3500 experts in our field and is only a short drive from Washington DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here we play host to some of the mostcutting-edgetechnology and lab spaces all designed to inspire collaboration and cross-functional science. We believe employeesbenefitfrom being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees stay happy and healthy. This includes a fitness center employee healthcare clinic electric vehicle charging stations dry cleaning full-servicecafeteriaand copy center. This is whereyoullfindnewly-designed activity-basedwork spacesto suit a variety of working styles while increasing collaboration between teams.

Summary of the Group

Biologics Engineering (BE)is responsible forthe discovery and optimization of next generation biologics to create biological drug candidates for all key therapeutic areas such as oncology respiratory and inflammation cardiovascularrenaland metabolic diseases.Wereconstantly pushing the boundaries of science to deliver life-changing medicines to patients with a passion for the development of in-housebiologicsdiscovery platforms and novel drug modalities to address unmet medical needs.

Main Duties & Responsibilities

We areseekinga skilled and highly motivated Scientist to enhance our High Throughput Production & Screening (HTPS) capabilities of biologics. The successful candidate will play a critical role in a dynamic group responsible for high-throughput cloning expression & purification of antibody therapeutics on amicrogram-to-milligramscale and be an advocate forutilizingvarious automation platforms. The selected individual will be a well-organized and a highly productive scientist that can design and execute experiments efficiently as well as analyzeinterpretand present data to multidisciplinary project teams

• Collaborate and work with a diverse group of scientists across all therapeutic areas to ensuretimelyprogress in research projects.

• Execute high-throughput cloningproductionand purification of protein therapeutics from mammalian expression systems using process automation and liquid handling robotics.

• Collaborate with automation engineers tointegrate liquid handling robotics and high-throughput analyticsinto production pipelines.

• Biochemicalbiophysicaland functional profiling of antibodies and recombinant antibody fragments.

• Ability to solve process development problems and implement improved procedures.

Education & Experience Requirements

• Masters degree with hands-on experience in antibody engineering cloning and expression or protein characterization (e.g. UPLC mass spectrometry)1 YOE

• Bachelors degree with4 years of relevant industry or academic research experience

Required Skills

• Expertisein protein purification techniques and in vitro analytical methods for protein characterization including SEC SDS-PAGE HPLC ELISA and BLI.

• Proven experience in the expression purification and comprehensive biochemical/biophysical characterization of various antibody formats (e.g. IgG Fab scFvbispecifics).

• Knowledgeinoptimizingand troubleshooting automation techniques with hands-on experience designing automated workflows.

• Ability tofollow well established SOPs effectively plan and organize work activities and prioritize task completion to meet project deadlines.

Desired Skills

• Experience in tissue cultureteftherchniquesandprotein characterization assays.

• Experience working with multiple antibody formats troubleshoot common downstream challenges such as low recoveryaggregationand purities.

• Automation experience with liquid handlersGreenbutton Go and otherplatformsa plus.

• Strong interpersonal and communication skills as well as the ability to work within teams.

• Goodwritten and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management.