Scientist I, Process Development

Position Summary:

The Scientist in LGC Axolabs Process Development will be responsible for independent optimization of scale up/down solid-phase oligonucleotide synthesis purification concentration conjugation and downstream processing steps in preparation for handover to routine manufacturing. This role involves working with cross-functional teams to ensure successful execution of each campaign including troubleshooting technical issues.

LGC Axolabs has an extensive ever-evolving global client base along with impressive technical capabilities within a state-of-the-art GMP facility. As the needs for the organization continue to grow we are seeking technically skilled and motivated candidates who can contribute to innovative solutions in oligonucleotide process development. The successful candidate will be detail-oriented proficient in chemistry techniques and capable of working independently while collaborating across teams to meet project goals. The Scientist will work under the guidance of a Lead Senior Scientist and/or the Process Development Manager and will interface with internal and external stakeholders.

Areas of Responsibility:

The Scientist is responsible for independent optimization and execution of all unit operations of custom oligonucleotide manufacturing including but not limited to: solid phase synthesis cleavage and deprotection preparative HPLC purification conjugation chemistry ultrafiltration/diafiltration and lyophilization. Also included will be sample preparation of samples to the Analytical Development Team.

To perform this job successfully an individual must be able to perform each essential function satisfactorily.

Essential Functions: 

• Independently prepare solutions samples and instrumentation to support development procedures
• Advanced data interpretation and troubleshooting of process or instrumentation issues
• Collaborate with Senior Scientists in developing experimental designs and technical strategies
• Author SOPs and other analytical documents (e.g. Project Plan QPP TDR) with minimal oversight
• Basic understanding of relevant regulatory and pharmacopeia guidelines (FDA/ICH/USP) to ensure compliance in tech transfer activities.
• Actively participates in internal & client-facing technical discussions

Qualifications :

Minimum Qualifications:

• Bachelors degree or equivalent experience in Chemistry Biology or a related subject area with 4 years of applicable experience or Masters degree or equivalent experience with 2 years in a related field
• Strong communication skills both written and verbal to effectively collaborate with internal cross-functional teams and external partners
• Demonstrated dedication to scientific excellence and alignment with LGCs core values and quality standards
• Proficiency in Microsoft Office Outlook Word Filemaker Pro IFS and Excel
• Self-starter with strong problem-solving skills and the ability to work independently and with the broader team

Preferred Qualifications:

• Technical understanding of oligonucleotide manufacturing processes and hands-on experience with relevant chemistry techniques equipment and methods
• Working knowledge of ChemDraw and Unicorn software (Synthesis and Purification)
• Prior experience in a GMP-regulated environment within a CMO/CDMO or pharmaceutical manufacturing setting

Physical Requirements:

The physical requirements outlined here reflect those that an employee must satisfy to effectively carry out the essential duties of this position. Reasonable accommodations can be provided to assist individuals with disabilities in performing these essential duties.

Additional Information :

The typical pay range for this role is:

Minimum: $72666 USD per year

Maximum: $121109 USD per year

This range represents the low and high end of the anticipated salary range for the California-based position. The actual base salary will depend on several factors such as experience skills and location.

About LGC:

LGC is a major international life sciences tools company delivering key components and solutions to fast-growing application areas in human healthcare and applied market segments. Our high-quality product portfolio features important tools for genomic analysis and quality assurance applications appreciated for their performance quality and scope.

Our values

• PASSION
• CURIOSITY
• INTEGRITY
• BRILLIANCE
• RESPECT

Equal opportunities

At LGC we hold the conviction that every applicant and employee should be appreciated for their distinct skills regardless of age disability race color ethnic or national origin sex sexual orientation gender reassignment marital or civil partnership pregnancy or parental leave religion or belief. Shortlisting interviewing and selection procedures are consistently performed without bias toward gender sexual orientation marital status color race nationality ethnic or national origins religion or belief age or trade union membership.

For more information about LGC please visit our website

#scienceforasaferworld

Remote Work :

No

Employment Type :

Full-time