Staff Software Engineer, Variant Classification

Labcorpis seeking aStaff Software Engineer Variant Classificationto join ourLabcorpGeneticsteam.

Work Schedule:This is a fulltime exempt (salaried) position assigned to a First Shift schedule with standard business hours of Monday through Friday 8:00 a.m. to 5:00 p.m. in your local time zone.Business needs may occasionally require flexibility in work hours including earlier later or additional hours with reasonable notice provided when possible.

Applicants who live within 35 miles of either the Burlington NC or Durham NC location will follow a hybrid schedule. This schedule includes a minimum of three in-office days per week at an assigned location either Burlington or Durham supporting both collaboration and flexibility.

Job Responsibilities:

• Design and build tools that define store and provide meaningful variant sample and test level information to supportaccuratevariant interpretation and report generation

• Develop andmaintainsystems that translate raw bioinformatic data into variant and sample level information including registration normalization observation groups and quality metrics

• Scale andoptimizestorage of sample level information to support growing data needs

• Sourcemaintain and provide annotations at the variant level necessary foraccuratevariant interpretation

• Automate evidence placement and classification for variant interpretation

• Support test content and assay development initiatives

• Collaborate with data scientists variant scientists and software developers to design and implement solutions that meet stakeholder requirements

Minimum Qualifications:

• Bachelors degree with 10 or more years of recent professional software development experience

• 10 or more years of experience with Python (intermediate level or higher)

• 10 or more years of experience with relational databases and web development frameworks

• 10 or more years of experience with front-end technologies (e.g. React Angular JavaScript/TypeScript HTML/CSS)

• 10 or more years of experience with RESTful APIs and microservices architecture

• 10 or more years of experience with CI/CD pipelines and DevOps practices

• 10 or more years of experience with cloud platforms (AWS Azure or GCP)

Preferred Qualifications:

• Masters Degree or Ph.D. in Bioinformatics/Computational Biology or life sciences

• 8 or more years of experience mentoring and developing senior and junior engineers across multiple teams

• 8 or more years of experience defining technical vision and driving multi-year roadmaps

• 3 or more years of experience with bioinformatic tools and annotation

• 3 or more years of experience with variant databases and genomic data resources (e.g.ClinVargnomAD HGMD)

• 3 or more years of experience in Spark text mining natural language processing semantic enrichment ontologies data mining or machine learning/AI

• 3 or more years of experience with public-domain biomedical terminologies (e.g.MeSH NCIt HGNC)

• 3 or more years of experience translating complex scientific questions into information solutions

Additional Job Standards:

• Owns and delivers product or platform goals across multiple years and teams setting a high standard for technical outcomes and delivery

• Defines the vision scope and technical approach for large business-impacting projects with organization-wide implications

• Identifies prioritizes and drives solutions to ambiguous open-ended problems across multiple teams

• Influences the roadmaps of partner teams to align with and achieve broader business goals

• Serves as a role model and technical authority for engineers across multiple teams

• Effective verbal and written communicator with both scientific and non-scientific audiences

• Effective with GitHub Copilot Claude Code or similar LLM tools to accelerate coding testing and documentation

AboutLabcorpGenetics
Labcorp Genetics (formerlyInvitae) is dedicated to bringing comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. The Variant Classification team builds andmaintainsthe tools that define store and provide meaningful and detailed variant sample and test level information to supportaccuratevariant interpretation and report generation. Our services supportinterpretation reportingof genetic variants and assay development across a suite of critical platforms including SDS VDB ArgusiVEP Evidence ServiceMoonPy Cerebro Universal Transcript ArchiveSeqRepo and Assay CMS.

AtLabcorpwe have a passion for helping people live happy and healthy lives. Every day we provide vital information that helps our clients and patients understand their health. If you are passionate about helping people and have a drive for service thenLabcorpcould be a great next career step!

Application Window:5/1/2026

Pay Range:$100K - $198K/yr

All job offers will bebased on a candidates skills and prior relevant experience applicabledegrees/certificationsas well as internal equity and market data.

LBP Only:The position is also eligible for an annual bonus under the Labcorp Bonus are payable based on corporate and/or business segment performance and are subject to individual performance modifiers.

Benefits:Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including: Medical Dental Vision Life STD/LTD 401(k) Paid Time Off (PTO) or Flexible Time Off (FTO) Tuition Reimbursement and Employee Stock Purchase regularly scheduled to work less than 20 hours Casual Intern and Temporary employees are only eligible to participate in the 401(k) who are regularly scheduled toworka 7 on/7 off schedule are eligible to receive all the foregoing benefits except PTO or FTO. For more detailed information pleaseclick here.