Senior Director, Head of R&D of the Future (RDoF)

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Job Description

Role Purpose:

The Senior Director Head of R&D of the Future leads the strategy integrated execution and value realization of Takedas R&D of the Future (RDoF) programa multiyear transformation to build a differentiated technologyenabled R&D engine.

This role serves as a crossR&D integrator driving alignment across R&D leaders on priorities and tradeoffs enabling coordinated execution across initiatives and ensuring measurable outcomes across transformation enablers (including data and technology). The Senior Director ensures program designs and new ways of working are scalable across R&Ds GCMaligned multihub model supporting consistent adoption and sustained performance across geographies.

Key Responsibilities:

1) Strategy Outcomes and Value Realization

• Lead the R&D of the Future strategy including ambition outcomes and KPI framework across R&D functions and initiatives.

• Drive disciplined value realization by ensuring clear business cases defined success metrics leadership accountability and ongoing ROI tracking.

• Establish performance reporting and management routines that maintain momentum and drive delivery through implementation and evolution of the program.

2) Senior Leader Alignment Across R&D and Enterprise Transformation

• Align the RDoF portfolio with broader enterprise transformation priorities through close partnership with enterprise transformation teams (e.g. GCM).

• Act as the primary integrator between R&D of the Future and R&D functional priorities ensuring coherence clarity and mitigation of competing change demands.

• Influence senior R&D leaders to drive accountability for decisions commitments and outcomes across the program.

3) Governance Decision Making and Escalation (Portfolio Control Tower)

• Design and operate fitforpurpose governance and escalation mechanisms that clarify decision rights and enable initiativelevel ownership within defined guardrails.

• Lead prioritization sequencing and tradeoff discussions across initiatives and functions to maximize delivery momentum and realized value.

• Proactively identify and address interdependencies and risks by mobilizing cross functional leaders.

4) Integrated Program Management and Cross Initiative Connectivity

• Set program direction shared operating mechanisms and common processes (e.g. governance financial tracking strategic priorities) to connect initiatives and enable consistent execution.

• Build and evolve a strong program management capability / PMO providing leadership visibility into progress milestones risks and dependencies.

• Enable open communication and knowledge sharing across initiatives to avoid duplication and accelerate adoption of effective practices.

5) EndtoEnd Lean Process Redesign at Scale

• Lead endtoend Lean redesign of priority R&D value streams to improve cycle time quality compliance and productivity integrating people process and technology into a coherent target state.

• Ensure redesigned processes support GCM aligned multihub execution balancing standardized core workflows controls and metrics with fitforpurpose local adaptation.

• Partner with R&D Functions Therapeutic Areas and enablement leaders (including data and technology) to embed enabling capabilities and ensure scalable deployment.

• Establish operating rhythms (governance KPI cadence continuous improvement mechanisms) to sustain performance and consistency across hubs over time.

6) Change Leadership Communications and Adoption

• Champion adoption of new ways of working and enabling technologies across R&D through visible leadership engagement.

• Develop and deliver consistent communications to articulate strategy progress decisions required and realized value.

7) People Leadership and Team Development

• Lead and develop the central R&D of the Future team fostering accountability collaboration and an environment that enables high performance and growth.

Decision Rights:

This role leads and operates governance performance management and value tracking for the R&D of the Future portfolio; establishes operating guardrails; and drives prioritization sequencing and escalation to resolve crossfunctional and crosshub tradeoffs.

Initiative Leads retain accountability for daytoday delivery within the governance and guardrails defined by this role.

Minimum Requirements / Qualifications:

Required:

• Substantial progressive experience in the pharmaceutical or biotech industry with a significant focus on R&D environments (e.g. Development R&D Operations Portfolio/Program Leadership or R&D transformation roles).

• Demonstrated ability to drive complex program decisions hold partners accountable and build trust and influence across R&D.

• Experience leading multiinitiative portfolios requiring prioritization sequencing and tradeoff management.

• Proven success driving largescale crossfunctional transformation initiatives with measurable value realization.

• People leadership and team management experience.

Preferred:

• PhD in a scientific discipline is strongly preferred (or MBA/advanced degree with equivalent industry and leadership experience).

• Strong strategic and domain expertise in Development with digital data and AI fluency in an R&D environment.

• Experience integrating data and technology foundations into process optimization and redesigned ways of working.

• Track record of operating with an R&Dwide perspective coordinating priorities across functions and geographies.

• Advanced degree (or equivalent experience).

Work Model / Travel:

• Hybrid (Cambridge MA): Based in Cambridge MA with a hybrid working model aligned to business needs.

• Member of the R&D Operational Excellence Leadership Team partnering with R&D leaders to drive alignment and accelerate transformation outcomes.

• Leads through a core team of 58 direct reports and significant indirect influence across a global crossfunctional matrix.

• 1020% travel to support global stakeholder engagement and multihub deployment.

This position is currently classified as hybrid in accordance with Takedas Hybrid and Remote Work policy.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees and we strive to be more transparent with our pay practices.

For Location:

U.S. Base Salary Range:

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors including the qualifications of the individual applicant for the position years of relevant experience specific and unique skills level of education attained certifications or other professional licenses held and the location in which the applicant lives and/or from which they will be performing the actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical dental vision insurance a 401(k) plan and company match short-term and long-term disability coverage basic life insurance a tuition reimbursement program paid volunteer time off company holidays and well-being benefits among others. U.S. based employees are also eligible to receive per calendar year up to 80 hours of sick time and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race color religion sex sexual orientation gender identity gender expression parental status national origin age disability citizenship status genetic information or characteristics marital status status as a Vietnam era veteran special disabled veteran or other protected veteran in accordance with applicable federal state and local laws and any other characteristic protected by law.

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