Executive Director, Head of R&D of the Future

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Job Description

Role Purpose:

The Executive Director Head of R&D of the Future is accountable for the strategy integrated execution and value realization of Takedas R&D of the Future programa multi-year transformation to build a differentiated technology-enabled R&D engine. This leader serves as the crossR&D integrator enabling the portfolio aligning leaders on priorities and trade-offs and ensuring measurable outcomes across initiatives and enablers (including data and technology). The role ensures program designs and new ways of working are scalable across R&Ds GCM-aligned multi-hub model enabling consistent adoption and durable performance across geographies.

Key Responsibilities:

1) Strategy Outcomes and Value Realization

• Own the R&D of the Future strategy including ambition outcomes and KPI framework across R&D functions and program initiatives.

• Drive end-to-end value realization discipline: ensure clear business cases success metrics leadership accountability and ongoing ROI management.

• Establish transparent performance reporting and management routines to sustain momentum and outcomes through implementation and evolution of the program.

2) Executive Alignment Across R&D and Enterprise Transformation

• Align the portfolio to enterprise priorities through connectivity to enterprise transformation stakeholders and related initiatives (e.g. GCM).

• Serve as the senior integrator between R&D of the Future and R&D functional priorities ensuring connectivity coherence and minimization of competing change burdens.

• Drive senior stakeholders to be accountable for decisions commitments and outcomes across the program.

3) Governance Decision-Making and Escalation (Portfolio Control Tower)

• Establish agile fit-for-purpose governance and escalation paths that clarify decision rights and enable empowered initiative-level execution within defined guardrails.

• Lead prioritization sequencing and trade-off discussions across initiatives and functions to maximize delivery momentum and value realization.

• Proactively remove roadblocks by mobilizing cross-functional leadership and resolving interdependency risks.

4) Integrated Program Management and CrossInitiative Connectivity

• Set program direction shared operating mechanisms andwhere neededcommon processes (e.g. governance finance strategic priorities) to connect initiatives and enable consistent execution.

• Evolve an empowered program management capability/PMO that provides leadership visibility to progress milestones risks and dependencies.

• Enable transparent communication and knowledge-sharing across initiatives to avoid duplication and accelerate adoption of best practices.

5) End-to-End Lean Process Redesign at Scale

• Lead end-to-end Lean redesign of priority R&D value streams to improve cycle time quality compliance and productivity integrating people process and technology changes into a coherent target state.

• Ensure redesigned processes are built for GCM-aligned multi-hub executionstandardizing core workflows controls and metrics while enabling fit-for-purpose localization across geographies and sites where required.

• Partner with R&D Functions Therapeutic Areas and enablement leaders (including data/technology) to embed enabling capabilities into redesigned processes and ensure scalable deployment across locations.

• Establish operating rhythms (governance KPI cadence continuous improvement mechanisms) to sustain performance and prevent divergence of ways of working across hubs over time.

6) Change Leadership Communications and Adoption

• Champion adoption and leadership endorsement of new ways of working and enabling technologies across R&D.

• Develop consistent program messaging and communications to articulate strategy progress decisions required and realized value.

7) People Leadership and Team Development

• Lead and develop the central R&D of the Future team creating clarity accountability collaboration and an enabling environment for performance and growth.

Decision Rights:

• This role owns program governance performance management and value realization for R&D of the Future; sets guardrails and operating mechanisms; and drives prioritization sequencing and escalation to resolve cross-functional and cross-hub trade-offs.

• Initiative Leads remain accountable for day-to-day initiative delivery within the portfolio guardrails and governance established by this role.

Minimum Requirements / Qualifications:

Required:

• 15 years of leadership experience across multiple R&D functions.

• Demonstrated ability to make key program decisions hold partners accountable and build trust and influence across R&D functions.

• Experience leading complex multi-initiative portfolios requiring sequencing prioritization and trade-off management across competing demands.

• Proven success leading enterprise-scale cross-functional transformations with measurable value realization.

• People leadership and team management experience.

Preferred:

• Deep strategic and domain expertise in Development and strong digital/data/AI fluency in an R&D context.

• Experience integrating data/technology foundations into business process optimization and redesigned ways of working.

• Track record of operating with an enterprise- and R&D-wide mindset coordinating priorities across functions and geographies.

• Advanced degree (or equivalent experience).

Work Model / Travel:

• Hybrid (Cambridge MA): This role is based in Cambridge MA with a hybrid working model aligned to business needs.

• As a member of the R&D Operational Excellence Leadership Team drive alignment across Operational Excellence priorities and partner with R&D leaders to accelerate transformation outcomes and value realization.

• Provide enterprise leadership through a core team of 58 direct reports and extensive indirect influence across a broad crossfunctional matrix aligning and mobilizing stakeholders to deliver endtoend transformation and value realization.

• 10-20% Travel may be required to support global stakeholder engagement and multi-hub deployment.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees and we strive to be more transparent with our pay practices.

For Location:

U.S. Base Salary Range:

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors including the qualifications of the individual applicant for the position years of relevant experience specific and unique skills level of education attained certifications or other professional licenses held and the location in which the applicant lives and/or from which they will be performing the actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical dental vision insurance a 401(k) plan and company match short-term and long-term disability coverage basic life insurance a tuition reimbursement program paid volunteer time off company holidays and well-being benefits among others. U.S. based employees are also eligible to receive per calendar year up to 80 hours of sick time and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race color religion sex sexual orientation gender identity gender expression parental status national origin age disability citizenship status genetic information or characteristics marital status status as a Vietnam era veteran special disabled veteran or other protected veteran in accordance with applicable federal state and local laws and any other characteristic protected by law.

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Job Exempt