Scientist, In Vitro Biology

The Role:

ModernaTX Inc. seeks a Scientist In Vitro Biology for its Cambridge Massachusetts location.

Heres What Youll Do:

• Manage technical oversight and troubleshooting of various types of laboratory equipment particularly for high-content confocal microscopy.

• Propose establish and implement a wide range of optical microscopy and imaging techniques to investigate the in vitro pharmacology of nucleic acid and LNP delivery systems.

• Investigate a variety of molecular biology and cell engineering methods to generate relevant in vitro model systems to interrogate nucleic acid and LNP delivery systems.

• Manage and oversee the technical work of co-ops or junior staff by providing scientific guidance and training.

• Develop quantitative methods to measure specific biomolecules of interest within cultured and primary cells and tissues as well as methods to study mRNA endosomal escape and mRNA and protein subcellular localization mRNA half-life and protein translation.

• Independently conceptualize generate and assemble in vitro cell-based data packages to support the advancement of Modernas nucleic acid and LNP delivery platforms and therapeutic pipeline.

• Identify introduce and validate new technical capabilities from regular review of the primary scientific literature for relevant biological applications.

• Identify and explore novel quantitative 3-dimensional and single-cell image analyses techniques for nucleic acid protein and lipid nanoparticle visualization.

• Identify initiate and foster research collaborations with nucleic acid delivery systems for infectious disease oncology immune disorders and rare disease indications across the internal and external ecosystem to enhance the understanding of Modernas technology platform.

• Effectively communicate scientific concepts experimental approaches and data analysis to multiple key research and development stakeholders across the company.

• Design and leverage immune activation assays to characterize nucleic acid cargo and LNP delivery systems.

• Develop and validate new tools to quantitatively measure intact LNP delivery with various routes of administration (with specific emphasis on nebulization).

• Serve as a technical and scientific subject matter expert for confocal imaging and cell-based assays with respect to nucleic acid delivery across cross-functional teams and provide supervision and training to new employees and non-subject matter experts on developed methods when necessary.

Heres What Youll Bring to the Table:

Minimum Requirements:

• Requires a Bachelors degree or foreign equivalent in Biotechnology Biology Biochemistry or related field and 6 years of post-baccalaureate progressive experience as a Principal Research Associate Senior Research Associate Biomanufacturing Specialist Research Assistant or related position within the Biotechnology industry.

• Must have 6 years of experience with:

  • Confocal Microscopy;

  • Conjugation of nucleic acids and antibodies;

  • Quantitative Image Analysis Pipelines (HALO FIJI Opera/Harmony Revvity); and

  • Immunofluorescence/IHC and Fluorescence in situ hybridization.

• Must have 4 years of experience with:

  • Practical experience with cell biology including cell culture cell line development cell panting and advanced optical microscopy techniques including super-resolution high-content live-cell 3-D and single-cell imaging;

  • High-throughput in vitro cell-based imaging assay development and liquid-handler automation;

  • In vitro pharmacology and mechanism-of-action characterization of LNP and mRNA and Nebulized LNP delivery;

  • RNA Endosomal Escape quantification via single molecule imaging galectin recruitment and qPCR;

  • Characterizing mechanism-of-action for biological drug products; and

  • Managing and overseeing the technical work of co-ops/interns and junior staff by providing scientific guidance and training.

• The salary range for this role is $109200 to $174600. This range reflects the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. The minimum target pay for this particular position based on its primary location is $143300 to $174600. An individuals placement within the range will depend on several factors including but not limited to specific competencies relevant education qualifications certifications experience skills performance and business or organizational needs.

Apply at (Job ID: 19097) or email resume and cover letter to with subject line: R19097.

ModernaTX Inc. seeks a Scientist In Vitro Biology for its Cambridge Massachusetts location.

Pay & Benefits

At Moderna we believe that when you feel your best you can do your best work. Thats why our US benefits and global well-being resources are designed to support youat work at home and everywhere in between.

• Best-in-class healthcare coverage plus voluntary benefit programs to support your unique needs

• A holistic approach to well-being with access to fitness mindfulness and mental health support

• Family planning benefits including fertility adoption and surrogacy support

• Generous paid time off including vacation volunteer days sabbatical global recharge days and a discretionary year-end shutdown

• Savings and investment opportunities to help you plan for the future

• Location-specific perks and extras

The successful candidate may be eligible for an annual discretionary bonus other incentive compensation or equity award subject to company plan eligibility criteria and individual performance.

#DNI

Pay & Benefits

At Moderna we believe that when you feel your best you can do your best work. Thats why our US benefits and global well-being resources are designed to support youat work at home and everywhere in between.

• Best-in-class healthcare coverage plus voluntary benefit programs to support your unique needs

• A holistic approach to well-being with access to fitness mindfulness and mental health support

• Family planning benefits including fertility adoption and surrogacy support

• Generous paid time off including vacation volunteer days sabbatical global recharge days and a discretionary year-end shutdown

• Savings and investment opportunities to help you plan for the future

• Location-specific perks and extras

The successful candidate may be eligible for an annual discretionary bonus other incentive compensation or equity award subject to company plan eligibility criteria and individual performance.