Director, Operational Excellence- Cell Therapy Manufacturing

About the role the Director Operational Excellence (OE) leads the network-wide OE agenda for AstraZenecas autologous Cell Therapy. You will establish basic conditions and eliminate waste across the vein-to-vein value stream. You will operate in a matrix with site-based OE Leads. It sets strategy governs the improvement portfolio and delivers measurable outcomes in cost productivity service quality safety and compliance. Additionally it builds sustainable capabilities for scale.

You Will:

• Lead end-to-end value stream mapping. Deploy Hoshin/strategy deployment to translate targets such as COGM capacity and service into a governed portfolio. This portfolio have clear owners milestones risks and benefits. Additionally create standardized COGM/productivity dashboards and benefit tracking with Finance.

• Lead programs (cycle time labor models MES/EBR enablement yield changeovers/scheduling deviation reduction automation/technology insertion). Apply the AZ Lean Model (A3 VSM standard work daily/tier management leader standard work adapted SMED).

• Facilitate development of business processes for training batch execution deviations and patient/lot scheduling and logistics.

• Lead Kaizen events; scale best practices across the Cell Therapy Development and Operations.

• Define basic conditions for Cell Therapy Manufacturing Sites and build capability at all levels; coach leaders and value stream owners

• Partner with Supply Chain to vein-to-vein flow slotting and cold-chain logistics safeguarding Chain of Identity/Chain of Custody.

• Ensure improvements uphold safety patient focus and cGMP for ATMPs (including GAMP and data integrity). Partner with Quality to reduce human error and increase First Pass Success and right-first-time performance.

• Align senior leaders on priorities and resources; communicate impact through governance forums.

You Have :

• Bachelors in engineering/Life Sciences or related; advanced degree preferred.

• 10 years in GMP manufacturing; 5 years leading programs.

• Recognized Lean Six Sigma Black Belt or equivalent depth of OE expertise.

• COGM/productivity improvements using lean digital and analytics.

• Expertise in value stream management and lean (Hoshin A3 VSM standard work tier/visual management leader standard work); Genba execution.

• Command of cGMP data integrity and GAMP; experience with MES/EBR/LIMS and other digital systems

• Track record in cross-site program leadership portfolio governance and benefits realization with Finance.

• Demonstrated experience in Influence without authority change leadership and process/project/risk/Analytical skills.

Date Posted

Closing Date

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