Postdoctoral Researcher Ellerby lab
Share
Job Location:
Novato, CA - USA
Yearly Salary:
USD 73760 - 81440
Posted on:
6 days ago
Vacancies:
1 Vacancy
Job Summary
LAB OVERVIEW
Dr. Lisa Ellerbys laboratory at the Buck Institute for Research on Aging investigates the molecular
mechanisms underlying age-related neurodegenerative diseases and develops novel small molecule and protein therapeutics for brain aging. We employ a rich toolkit including iPSC-derived neurons and organoids CRISPR/Cas9 single-cell analysis proteomics genomics and phenotypic screening to understand why neurological diseases increase so dramatically with age and to identify new ways to prevent and treat them.
POSITION SUMMARY
We are seeking a motivated Postdoctoral Researcher to lead a high-throughput screening (HTS) program focused on brain aging and neurodegeneration. This is an exciting opportunity to drive discovery at the intersection of chemical biology iPSC-based disease modeling and advanced high-content imaging with a specific focus on OXR1 and APOE2 biology. The successful candidate will develop and execute screens to identify small molecules that reverse aging phenotypes or build cellular resilience in neuronal models.
KEY RESPONSIBILITIES
Required
The Buck Institute is the worlds leading independent research institute dedicated to understanding and combatting the diseases of aging. Postdoctoral researchers benefit from a highly collaborative interdisciplinary environment state-of-the-art core facilities strong career development programming and proximity to the vibrant Bay Area biotech ecosystem.
The Buck Institute is an equal opportunity employer committed to fostering a diverse and inclusive workplace. We strongly encourage applicants who will contribute to the diversity of our community.
COMPENSATION & BENEFITS
Please submit a CV a brief statement of research interests (1-2 pages) and contact information for three references.
For Additional Information:
Professor Lisa M. Ellerby Ph.D.
emailprotected
Dr. Lisa Ellerbys laboratory at the Buck Institute for Research on Aging investigates the molecular
mechanisms underlying age-related neurodegenerative diseases and develops novel small molecule and protein therapeutics for brain aging. We employ a rich toolkit including iPSC-derived neurons and organoids CRISPR/Cas9 single-cell analysis proteomics genomics and phenotypic screening to understand why neurological diseases increase so dramatically with age and to identify new ways to prevent and treat them.
POSITION SUMMARY
We are seeking a motivated Postdoctoral Researcher to lead a high-throughput screening (HTS) program focused on brain aging and neurodegeneration. This is an exciting opportunity to drive discovery at the intersection of chemical biology iPSC-based disease modeling and advanced high-content imaging with a specific focus on OXR1 and APOE2 biology. The successful candidate will develop and execute screens to identify small molecules that reverse aging phenotypes or build cellular resilience in neuronal models.
KEY RESPONSIBILITIES
- Develop and lead a high-throughput screening (HTS) effort to identify small molecules that reverse aging to a youthful state or build resilience with a focus on OXR1 and APOE2 biology.
- Design and execute high-content imaging workflows and Cell Paintingbased phenotypic profiling.
- Develop and apply iPSC-derived neuronal and organoid models for disease-relevant screening.
- Operate and integrate complex robotic automation platforms and multi-instrument workflows.
- Analyze complex imaging outputs using Python and R; apply pathway analysis and data visualization tools.
- Collaborate with biologists across the Buck Institute to standardize protocols and experimental design.
- Contribute to peer-reviewed publications as a leading author and apply for fellowship/grant funding.
- Participate in institutional seminars programs and the broader Buck Institute scientific community.
Required
- PhD in Neuroscience Biology Chemistry Chemical Biology or a related field
- Hands-on experience with HTS assay development and laboratory automation platforms
- Experience with high-content imaging and analysis pipelines (e.g. CellProfiler Columbus or
similar) - Proficiency in Python and/or R for image and data analysis
- Demonstrated ability to drive independent research and a strong publication record
- Experience with iPSC-derived neuronal models or cerebral organoids
- Familiarity with Cell Painting/image-based morphological profiling
- Experience with senescence biology neurodegeneration or aging-related pathways.
The Buck Institute is the worlds leading independent research institute dedicated to understanding and combatting the diseases of aging. Postdoctoral researchers benefit from a highly collaborative interdisciplinary environment state-of-the-art core facilities strong career development programming and proximity to the vibrant Bay Area biotech ecosystem.
The Buck Institute is an equal opportunity employer committed to fostering a diverse and inclusive workplace. We strongly encourage applicants who will contribute to the diversity of our community.
COMPENSATION & BENEFITS
- Salary Range: $ annually commensurate with experience and qualifications
- Comprehensive benefits package including health insurance paid parental leave childcare assistance generous paid time off and a 401(k) with 5% employer match
Please submit a CV a brief statement of research interests (1-2 pages) and contact information for three references.
For Additional Information:
Professor Lisa M. Ellerby Ph.D.
emailprotected
Required Experience:
Manager
