Sr. Principal Scientist, Oncology Translational Research, Prostate

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at

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About Innovative Medicine

Ourexpertisein Innovative Medicine is informed and inspired by patients whose insights fuel our science-based like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at Oncology

Ourexpertisein Innovative Medicine is informed and inspired by patients whose insights fuel our science-based like you work on teams that save lives by developing the medicines of tomorrow.

Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at areseekinga highly motivated Principal or Senior Principal Scientist in Translational Research and Biomarker Strategy to lead biomarker and translational science efforts across clinical development programs in prostate cancer.

This role will drive the design implementation and interpretation of biomarker strategies supporting early and late-stage clinical trials including both registrational and exploratory studies. The successful candidate will work within a highly matrixed development environment to integrate translational science with clinical development ensuring that biomarker data informs patientselection pharmacodynamic assessment and mechanisms of response and resistance.

The candidate will partner closely with clinical development biostatistics diagnostics regulatory discovery research and external academic collaborators to translate biological insights into actionable clinical strategies.

This role will open the opportunity for the fitting candidate to gain experience in the novel first in class pan-tumor potential heterobifunctional small molecules called RIPTACs that induce tumor cell apoptosis distinct from PROTACs.

This position requires deep scientificexpertise strong organizational and project leadership skills and the ability to communicate complex scientific findings effectively to diverse audiencesand influence across a team matrix. Details of the role include but are not limited to:

TranslationalResearch& Biomarker Strategy

• Lead development and execution of integrated translational research internal and external scientific endeavors and biomarker strategies for prostate cancer drug development programs.
• Design biomarker plans aligned with therapeutic mechanism of action and clinical development objectives pharmacodynamic (PD) target engagement (TE)responseand resistance
• Guideselectionand prioritization of biomarkers across multiple platforms including:
• Genomics and transcriptomics
• Circulating biomarkers (ctDNA plasma proteins)
• Tissue-based molecular and spatial biomarkers
• Immunologic and tumor microenvironment profiling
• Digital pathology and computational biomarker approaches
• Ensure biomarker strategies address key clinical questions including:
• Patient stratification and enrichment
• Pharmacodynamic biomarkers
• Target engagement
• Mechanisms of response and resistance
• Design and projectmanageinvitro experiments to reveal novel combination strategiesresponseand resistancepatternswithother pipeline assets.

Clinical Trial Integration

• Partner with clinical development teams to integrate biomarker hypotheses into clinical trial protocols biomarker analysis plans and statistical analysis frameworks.
• Design biomarker sample collection and analysis strategies for Phase IIII clinical trials.
• Ensure biomarker analyses support key decision points in development programs.
• Collaborate with clinical operations and laboratory partners to ensure effective biomarker implementation.

Biomarker Governance & Execution

• RepresentTranslationalResearchin cross-functional governance discussions and program team meetings.
• Coordinate biomarker activities across internal laboratories CRO partners and external collaborators.
• Ensure biomarker assays are fit-for-purpose and analytically robust for clinical trial use.
• Support documentation of biomarker strategies relevant to regulatory interactions and submissions.

External Research Collaborations

• Evaluate and prioritize external translational research proposals and collaborations aligned with program strategy.
• Partner with academic investigators and technology providers to advance biomarker discovery and validation.
• Identifyemerging technologies and scientific approaches relevant to prostate cancer translational biology.

Data Integration & Interpretation

• Translate complex data into actionable insights that inform clinical developmentstrategy.
• Lead multidisciplinary interpretation of translational datasets integrating:
• Clinical outcomes
• Genomic and molecular data
• Pathology and tissue-based biomarkers
• Circulating biomarker data

Scientific Communication

• Prepare and present translational and biomarker findings to internal governance committees and cross-functional teams.
• Represent the company at major scientific conferences (e.g. ASCO AACR ESMO).with key opinion leaders and cross functional team members.
• Contribute to peer-reviewed publications and scientific presentationsand adhere to processes for best practices and oversight

Qualifications

Required Qualifications

• PhD in biomedical sciences (e.g. immunologycomputational biologycancer biology molecular biology pathology or related discipline)
• Postdoctoral training in a relevant biomedical field
• Minimum 3 years after postdoc of biopharmaceutical drug development experience
• Experience designing and implementing biomarker strategies in clinical trials
• Strong background in translational oncology and biomarker science
• Demonstrated ability tooperateeffectively in matrixed cross-functional teams
• Excellent scientific communication writing and presentation skills
• Strong organizational and project management capabilities

Preferred Qualifications

• Applied knowledge in data science: computational biology statistics report generation basic and advanced visualization of data using R and/or python tools and related skills
• Experience in prostate cancer biology and therapeutic development
• Experience with PROTACs RIPTACs and other novel cell modulating therapies
• Expertisein immunology tumor microenvironment biology or precision oncology
• Experience working with circulating biomarkers such as ctDNA or CTCs
• Familiarity with tissue-based biomarkers spatial biology or digital pathology
• Experience supporting registrational clinical trials

Subject to the terms of their respective plans employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical dental vision life insurance short- and long-term disability business accident insurance and group legal insurance.

Subject to the terms of their respective plans employees are eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).

This position is eligible to participate in the Companys long-term incentive program.

Subject to the terms of their respective policies and date of hire Employees are eligible for the following time off benefits:

• Vacation 120 hours per calendar year
• Sick time - 40 hours per calendar year; for employees who reside in the State of Washington 56 hours per calendar year
• Holiday pay including Floating Holidays 13 days per calendar year
• Work Personal and Family Time - up to 40 hours per calendar year
• Parental Leave 480 hours within one year of the birth/adoption/foster care of a child
• Condolence Leave 30 days for an immediate family member: 5 days for an extended family member
• Caregiver Leave 10 days
• Volunteer Leave 4 days
• Military Spouse Time-Off 80 hours

Additional information can be found through the link below.

anticipated base pay range for this position is: $137000 - $235750

Johnson & Johnsonisan Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federalstateor local law. We actively seek qualified candidates who areprotectedveterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnsoniscommitted to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to requestan accommodation external applicants please contact us via internal employees contactAskGSto be directed to your accommodation resource.

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