Senior Project Manager – PMO (GMP & non-GMP)

Summary of Role:

The Senior Project Manager PMOis responsible forend-to-end delivery of sophisticated capital and infrastructure projects across AstraZenecas U.S. R&D network including GMP and non-GMP role leads projects from early concept through closeout partnering with Site Leadership and Global stakeholders to define scope evaluate infrastructure capacity and impacts assess risk and build capital strategy early in the lifecycle. The Senior Project Manager ensures initiatives are aligned with site strategy and executable within active regulated role provides full project lifecycle accountability scope budget schedule risk governance and partner alignment ensuring delivery of safecompliant and operationally sustainable Senior Project Manager leads cross-functional teams including Senior Project Engineers external design firms contractors Quality SHE and Facilities to ensure projects are implemented with operational excellence and regulatory integrity.

Responsibilities:

Project Leadership & Accountability

• Lead front end planning: scope definition feasibility infrastructure capacity assessments and cost modeling.

• Translate business needs into clearly defined charters scope and key assumptions.

• Develop and defend capital investment cases incorporating cost risk and lifecycle considerations.

• Identifyenabling projects sequencing constraints and long-term site impacts during early planning.

• Lead capital projects from initiation through closeout within active GMP and R&D environments.

• Own project scope budget schedule and risk profile.

• Lead capital forecasts cash flowplanningand financial tracking.

• Ensure projects align with long-term site master planning strategy.

Governance & Compliance

• Ensure adherence to PMO governance framework and stage-gate processes.

• Establish early-stage risk identification and mitigation strategies to reduce downstream execution uncertainty.

• Lead risk assessments and mitigation planning.

• Lead prioritization and formal change management to protect cost and schedule commitments.

• Ensure regulatory safety and environmental compliance throughout execution.

• Raise and resolve project risksimpactingcostscheduleor operational readiness.

Stakeholder & Cross-Functional Leadership

• Serve asprimaryproject interface for Site Leadership and Global partners.

• Influence senior partners toalign onscope definition funding strategy and risk tolerance.

• Align Engineering Quality SHE Procurement and Operations throughout planning and execution.

• Lead steering committee updates and executive reporting.

• Drive strong collaboration between GMP and non-GMP pillars.

Contractor & Vendor Management

• Leadselectionand oversight of design firms and contractors.

• Negotiate scope changes and lead contract performance.

• Ensure safe execution and adherence to project controls.

GMP & Technical Integration

• Partner with Senior Project Engineers to ensure technical rigor.

• Ensure validation and regulatory expectations are coordinated early in project lifecycle.

• Be responsible for commissioning and qualification strategy alignment.

Portfolio & Strategic Contribution

• Support capital prioritization decisions through project definition and cost clarity.

• Identifyproject interdependencies and sequencing risks across the capital portfolio.

• Contribute to multi-year capital planning.

• Identifyprogram-level efficiencies and standardization opportunities.

• Drive sustainability integration acrossprojectportfolio.

Experience and Education Requirements:

• Bachelors degree in Engineering Construction Management or relatedfield.

• 10 years of experience in capital project delivery in pharmaceutical/biotech or similar regulated industry.

• Validated experience managing projects >$10M.

• Strong financial competence and capital governance experience.

• Experience leading cross-functional multi-disciplinary teams.

• Front End Project Strategy & Definition

• Strategic Project Leadership

• Financial & Capital Management

• Executive Communication

• Risk & Governance Discipline

• Regulatory Awareness

• Organizational Influence

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing -person working gives us the platform we need to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay for this position ranges from $122859 to $184289. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors including market location job-related knowledge skills and addition our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) to receive a retirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an at-will position and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and market factors.

Why AstraZeneca:

Here you will help turn a rich complex pipeline into real treatments by uniting science disciplined execution and smart digital tools. You will collaborate with unexpected teams that challenge ideas and accelerate progress learning alongside peers who value kindness as much as ambition. With investment in cutting-edge capabilities and a clear focus on speed quality and sustainability your leadership will shorten the path from study start-up to submission and ultimately to patients who need our medicines.

Call to Action:

Step forward to lead the clinical programs that shape the next wave of medicinessend your CV today and help us deliver impact at speed!

Date Posted

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.