Executive Director, US Commercial Technology

Overview / Purpose

As VertexsUSportfolio and pipeline expand the Executive DirectorUSCommercial Technology is the senior technology leader accountable for endtoend technology partnership delivery outcomes and operational performance forUSCommercial priorities across multiple business units and horizontal capabilities. This role serves as the single accountable technology point of contact for the SVPUSCommercial leadershipandrepresentsDTEfunction acrossUScommercialization planning governance and execution. The role leads a team of senior technologyand AIleaders and orchestrates shared/platformteams todeliver measurable improvements in customer engagement gotomarket effectiveness patient services and contact center experience operational excellence and compliant use of data and AI in a regulated environment.

Organization Scale

• Peoplesleadership scope: 23 employees (direct and indirect).

• Financial scope: $65M annual budget responsibility (operatingand/or vendor/program spend within remit).

Direct Reports / Scope (2026 design)

• Senior Directors leadingUStechnology partnership and delivery for:

• (1) PainCFMarket Access & US Commercial Operations;

• (2) KidneyandPatient ServicesProgram; and

• (3) Heme/T1DCell and Gene Therapies (CGT) commercialization technology.

• Matrixedpartnershipwith global platformleadersfor CRM/digital engagement customer engagement platforms and AI product management to ensureUSrequirements governance and adoption are delivered.

Key Responsibilities

Executive Business Partnership & Stakeholder Leadership

• Serve as senior technology advisor toSVP of US commercial andUSCommercial leadershipteam;anticipateneeds shape demand and influence business decisions through clear evidencebased recommendations.

• Deliver thought leadership and guidance through the US Commercial AI Transformation

• Represent DTEas the senior technology leader forUSCommercialforumsandensure alignment across Commercial Medical Legal/Compliance Privacy Security Data Governance and Finance partners.

• Communicate complex technology data and AI topics in crisp business terms; escalate risks and decisions with clear options.

USCommercial Technology Strategy

• Define and continuously refine theUSCommercial Technology strategy and multiyearinvestmentroadmap aligned toUScommercial goals and the broader Technologyand AIvision.

• Translate strategy into an integrated portfolio across business capabilities (BU partnership patient services market access/contracting field excellence) and enabling technology (data/analytics AI adoption integration quality/compliance).

• Establish the operating model and decision rights forUSCommercial Technology clarifying what is owned within theteamvs. what is delivered via shared/global platform teams.

Portfolio Governance Value Delivery & Operational Excellence

• Own prioritization delivery governance and value realization for theUSCommercial Technology portfolio; ensure transparent tradeoffs disciplined execution and measurable outcomes.

• Ensure reliable run performance for businesscritical systems and services within scope including incident problem change and release management expectationsappropriate forregulated commercial operations.

• Establish OKRs and value metrics tied to commercial outcomes (e.g. customer engagement effectiveness cycle time productivity quality and risk reduction) and report progress to senior business and technology leadership.

Platform Enablement & CrossteamIntegration

• DriveUSrequirements and adoption for shared/global platforms (e.g. CRM and digital engagementMartech customer engagement platforms) through tight partnership with platform owners and architecture leaders.

• EnsureUSCommercial capabilities are integrated endtoend (data flows identity/access content contracting patient services) and that solutions are interoperable and scalable across BUs.

• Lead vendor strategy and buyvsbuild decisions within scope; rationalize and manage vendor performance in partnership with procurement and platform owners.

AIStrategy andAdoption

• Partner with AI Product Management and data/analytics leaders toidentify prioritize and scale the highestvalueUScommercial AI and analytics use cases (e.g. field force excellence content lifecycle contracting and deal enablement patient services automation).

• Ensure responsible AI practices: promotional and regulatory compliance privacy/security guardrails model risk management andappropriate humanintheloopcontrols.

Financial Stewardship & Vendor Management

• Own budget planning forecasting and ongoing financial stewardship across the $65M spend in scope ensuring disciplined investment decisions and clear linkage to value and risk reduction.

• Drive cost transparency and ROI-based decision-making across programs and vendors; partner with Finance and Strategic Sourcing on contracts renewals and vendor performance management.

Risk Management Compliance & Controls

• Ensure systems and solutions within scope meet Vertex policies and applicable global/local regulations related to privacy security promotional compliance and data protection.

• Own thirdparty risk management expectations for vendors in scope; ensure business continuity and resilience planning is in place for critical services.

• Partner with Quality/Regulatory Security Privacy and Legal/Compliance to embed controls and audit readiness into delivery and operations.

People Leadership Talent & Culture

• Lead develop andretaina highperforming inclusive leadership team; build succession depth and strengthen capability in product data and AI delivery.

• Mature ways of working andcoachleaders on outcomesbased prioritization accountability and continuous improvement.

Minimum Qualifications

• 15 years of progressive experience in technology digital data or analytics roles including substantial experience leading commercialfacing technology organizations within life sciences or similarly regulated industries.

• 7 years leading leaders (e.g. Directors/Senior Directors) with accountability for multiportfolio delivery and operations.

• Deep Life Sciences Commercial domain and business processexpertisealong with working knowledge of major commercial technology software platforms (e.g.Veeva SalesforceSnowflakePowerBIModel N)

• Demonstrated success delivering business outcomes through commercial platforms and capabilities (e.g. CRM/digital engagement market access/contracting enablement patient services/contact center analytics) and scaling modern data/AI solutions responsibly.

• Ability to influence senior executives and governance bodies; exceptional executive communication skills.

• Strong working knowledge of security privacy data governance and regulatory requirements relevant to commercial operations.

• Demonstratedfinancial managementexperience (budget ownership vendor portfolio oversightforecastingand value tracking).