Engineering Platform Lead Oligonucleotides

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Engineering Platform Lead Oligonucleotides

Robust scalable manufacturing platforms are essential to delivering highquality clinical and commercial oligonucleotide products. At GSK this means deploying GMPcompliant fitforpurpose technologies across our internal manufacturing network and external partners to enable reliable scaleup seamless technology transfer and costeffective commercial supply.

The Engineering Platform Lead sits within Process Technologies Medicinal Global Clinical Manufacturing Organisation (GCMO) and acts as a platform engineering and GMP subjectmatter expert following products and processes across the endtoend development and manufacturing lifecycle. The focus is on ensuring product and process quality reproducibility scalability and longterm manufacturability.

As an Engineering Platform Lead you will be accountable for delivering efficient timely and costeffective clinical trial manufacturing in line with CMC project plans. You will also serve as the GMP manufacturing point of contact for designated platforms guiding platform selection and ensuring alignment with regulatory and operational expectations.

You will play a critical role in bridging Research Development and Manufacturing ensuring that new capabilities developed in early phases can be successfully implemented within a GMP environment and translated into clinical and commercial supply chains.

This role involves close collaboration with Drug Substance Development Drug Product Development GCMO Pilot Plants Contract Manufacturing Organisations (CMOs) MSAT and GSK manufacturing sites. Engineering Platform Leads are core members of the relevant Manufacturing Technology Teams (MTTs) and key contributors to GSKs oligonucleotide manufacturing strategy.

In this role you will

• Ensure that appropriate platforms are used for GMP clinical trial material manufacture with scalability manufacturability and commercial manufacture in mind.
• Provide technical expertise and lead aspects (project definition equipment selection procurement and commissioning / qualification) of internal GMP platform capital projects.
• Transfer platform knowledge as required to and from CMOs including the support of assets that have been acquired or in licensed as well as those arising from internal discovery programmes.
• Represent CM&SC in terms of platform stewardship and collaborate with Drug Substance Development Drug Product Development GCMO Pilot Plants CMOs and MSAT and GSC Manufacturing Sites.
• Support the generation and maintenance of Own and maintain product and process knowledge throughout the entire development life cycle bridging Research / Early Development and Commercial Manufacturing Operations.
• Embed QbD QF PDVS and GMPs in the GMP Mfg. network ensuring Quality is respected while speed and agility are retained by aligning product development strategies with these key initiatives.

Why you

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• Bachelors degree in chemical engineering Mechanical Engineering Chemistry Bioengineering Pharmacy or other relevant discipline experience in pharmaceutical manufacture and/or development.
• Experience with GMP manufacturing in Small Molecule drug substance biological drug substance and sterile manufacturing operations across clinical and commercial manufacture.
• Experience of Process Design Quality/ GMP Project Management Equipment maintenance and design in a pharmaceutical setting.
• Experience collaborating with cross-functional teams in a multicultural environment. Preparing and delivering written and verbal communications in a professional setting.
• Experience in leading a large matrix international organisation build successful collaborations within and outside GMP manufacturing.
• Ability to work independently and set your own direction.

Preferred Qualifications & Skills:

Please note the following skills are not necessary just preferred if you do not have them please still apply:

• Master or PhD in chemical engineering Mechanical Engineering Chemistry Bioengineering Pharmacy or other relevant discipline.
• Would be advantageous to have manufacturing scale-up or development experience of Oligonucleotide or peptide manufacture and enzyme reactions.
• Matrix management communication synthesis and analytical capacity presentation skills spoken & written English influencing and flexibility.
• Experience in facility design equipment procurement capital projects facility qualification and commercial manufacture are highly desirable.
• Solid understanding of regulatory requirements and the GSK QMS.
• A solid understanding of the connections with key stakeholders (Clinical Regulatory DS and DP development CMC Project Teams and GCMO CSC and GSC groups) is considered advantage.

Closing Date for Applications 7th May 2026

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Please take a copy of the Job Description as this will not be available post closure of the advert.
When applying for this role please use the cover letter of the online application or your CV to describe how you meet the competencies for this role as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK we have bold ambitions for patients aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines combining our understanding of the immune system with cutting-edge technology to transform peoples fosters a culture ambitious for patients accountable for impact and committed to doing the right thing making sure that we focus our efforts on accelerating significant assets that meet patients needs and have the highest probability of success. Were uniting science technology and talent to get ahead of disease together.

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Why GSK

Uniting science technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade as a successful growing company where people can thrive.

We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale.

People and patients around the world count on the medicines and vaccines we make so were committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients accountable for impact and doing the right thing is the foundation for how together we deliver for patients shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race color religion sex (including pregnancy gender identity and sexual orientation) parental status national origin age disability genetic information (including family medical history) military service or any basis prohibited under federal state or local law.

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