Principal Scientist Translational Muscle Biology

Make your mark for patients

We are seeking an exceptional Principal Scientist to join UCBs US Neuromuscular group based in Cambridge MA and contribute to translational biology drug discovery efforts with an emphasis on muscle biology. The candidate will be responsible for leading projects exploring new biology designing characterizing and deploying in vitro or in vivo models and other cellular/biochemical assays to be utilized in early drug discovery for multiple therapeutic programs and target discovery efforts. Collaborate in a matrixed team of scientists responsible for identification and knowledge building across pathobiological pathways and patient populations including those in neuromuscular disease related to nucleotide repeat expansions genetic mutations muscle atrophy mitochondrial/ lysosomal dysfunction or inflammation.

Responsibilities:

• Team leadership: Supervise and mentor junior scientists fostering a collaborative and innovative research environment.
• Project management: Oversee multiple projects ensuring timely delivery of milestones and effective resource allocation.

• Innovation: Identify and implement new technologies and methodologies to advance muscle cell biology and translational research.

• Model Development: Design characterize and validate primary cell or stem cell/3D models for therapeutic programs.
• Assay Execution: Conduct cell-based functional assays to characterize therapeutic hits or validate new targets that could require gene editing.
• Muscle biology: Perform in vivo and in vitro assays to enhance understanding of neuromuscular disease biology.
• Team Collaboration: Collaborate with cross-functional teams to integrate translational biology insights into therapeutic programs or new target proposals.
• Data Management: Document analyze and present data to internal teams.

Requirements:

• PhD with 12 years or MS Degree with 18 years in drug discovery biology cellular biology bioengineering or related field.

Competencies:

• Deep knowledge in muscle biology and translational assays
• Strong assay development and drug discovery knowledge
• Strong track record of publishing in high-impact journals and presenting at scientific conferences
• Deep experience with mammalian cell culture molecular and biochemical assays
• Strong attention to detail and enthusiasm for learning
• Proven ability to lead projects supervise and mentor scientists is a plus
• Knowledge in mitochondrial biology is a plus

Base Salary Range: $137600 to $180600

Are you ready to go beyond to create value and make your mark for patients If this sounds like you then we would love to hear from you!

About us
UCB is a global biopharmaceutical company focusing on neurology and immunology. We are over 9.000 people in all four corners of the globe inspired by patients and driven by science.

Why work with us
At UCB we dont just complete tasks we create value. We arent afraid to push forward collaborate and innovate to make our mark for patients. We have a caring supportive culture where everyone feels included respected and has equal opportunities to do their best work. We go beyond to create value for our patients and always with a human focus whether thats on our patients our employees or our planet. Working for us you will discover a place where you can grow and have the freedom to carve your own career path to achieve your full potential.

At UCB weve embraced a hybrid-first approach to work bringing teams together in local hubs to foster collaborative curiosity. Unless expressly stated in the description or precluded by the nature of the position roles are hybrid with 40% of your time spent in the office.

UCB is an equal opportunity employer. All employment decisions will be made without regard to any characteristic protected by applicable laws.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Please note should your enquiry not relate to adjustments; we will not be able to support you through this channel.