Clinical Pharmacometrician in CVRM (Associate DirectorSenior Scientist)

Do you have expertise and experience in PK PKPD mathematical/statistical modeling and simulation and Model Informed Drug Development (MIDD) and its application in drug development Would you like to apply your knowledge in a company that is dedicated to following the science and turning ideas into life-changing medicines If so this could be your next challenge!

We havean exciting opportunityfor an engaged and diligent individual to join our Clinical Pharmacology and Quantitative Pharmacology (CPQP) team at AstraZeneca at our vibrant site in Gothenburg Sweden in the role as a Clinical Pharmacometrician at an Associate Director or Senior Scientist level (depending on your background experience and skills). This is a global position that will support large- and small molecule projects across all phases of clinical development within the therapy area of Cardiovascular Renal and Metabolism.

Withinthe Clinical Pharmacology and Safety Sciences (CPSS) function at AstraZeneca we have a groundbreakingClinical Pharmacology and Quantitative Pharmacology (CPQP) organization with a diverse and uniquely skilled team of Clinical Pharmacometricians and Clinical Pharmacology Leads. You will thrive in an environment that inspires innovation encourages multidisciplinary team-working and collaboration with academia and rewards original scientific thinking.

What you will do
Working closely with clinical pharmacologists physicians statisticians and other scientists you will apply model informed drug development (MIDD) to contribute to clinical programs to support the design and interpretation of clinical studies and influence key decisions in early and late clinical development.

The work includes integration of relevant data such as dose information pharmacokinetics biomarkers and clinical endpoints within and across studies compounds and development stages. Use of simulations and pharmacometric/statistical analyses to inform trial and program designs and decisions are important focus areas for us.

In collaboration with clinical pharmacologists you will represent CPQP in cross-functional clinical project teams and be responsible for identifying and driving model informed drug development opportunities to accelerate and advise decision making. Based on your interest skills and experience you might also take on strategic planning and delivery of the clinical pharmacology strategy acting as a dual Clinical Pharmacometrician/Clinical Pharmacologist. You will communicate your findings within and outside of AstraZeneca and publish in peer reviewed journals.

Minimum requirements for the role

• PhD in pharmacometrics or mathematical/statistical modeling and simulation or other relevant area

• Strong quantitative skills (e.g. experience in population modelling statistics systems and translational pharmacology modelling)

• Strong technical knowledge and hands-on skills in PK and PK/PD modeling and simulation including training and experience with pharmacometric and statistical software (NONMEM R Stan Monolix Phoenix)

• Knowledge in pharmacology and drug targets

• Excellent oral and written communication skills

Desirable requirements

• 4 years of industry experience or equivalent in quantitative modelling and its application in drug development combined with ability to independently support clinical programs is required for Associate Director level (2 years for Senior Scientist)

• 2 years of industry experience or equivalent in quantitative modelling and its application in drug development combined is required for Senior Scientist level

• Track recordincreating and delivering onMIDD strategies in clinical drug development programs for both small and large molecules

• Early and late phase clinical development experience

• Understanding of clinical pharmacology aspects of drug development preferably in both a small and large molecule setting

• Recognized scientific expertise demonstrated by scientific publishing in the field of clinical pharmacometrics/pharmacology

• Knowledge in Cardiovascular Renal or Metabolism disease areas

• Familiarity with applications of artificial intelligence in drug development is a strong plus

Why AstraZeneca

At AstraZeneca we are at the forefront of medical innovation. We use our unique position as medical leaders across our enterprise and the healthcare ecosystem to shape the future of healthcare. We provide medical leadership across the whole product lifecycle - from advising on Research & Development investment decisions to leading pre-launch scientific efforts and accelerating evidence-based healthcare changes in the real world. We are networkers and influencers by our role as scientific ambassadors we thrive on working with people internally and externally.

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing -person working gives us the platform we need to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

So whats next

Are you prepared to bring your innovative ideas and fresh perspectives to the table If so you might be the candidate were seeking! Please submit your application by 3rd May 2026.

Please ensure your application includes your current CV and a cover letter highlighting your key strengths and explaining why you should be considered for the role.

Date Posted

Closing Date