T-Cell Engineering Scientist Cell Therapy Discovery and Translational Science Program

Strategic Role and Scientific Focus

The T-Cell Engineering Scientist will:

• Lead discovery and validation of novel targets for CAR-T TCR-engineered T cells and TIL-based therapies across hematologic malignancies and solid tumors.

• Develop strategies to enhance TIL expansion persistence functional fitness and tumor reactivity including genetic modification approaches to overcome exhaustion and immunosuppressive tumor microenvironments.

• Engineer and optimize CAR constructs co-stimulatory domains synthetic circuits safety switches and multiplex gene editing strategies to enhance therapeutic performance.

• Advance next-generation approaches such as armored CAR-T cells logic-gated systems dual-target strategies universal/allogeneic platforms and genetically enhanced TIL therapies.

• Collaborate closely with genome editing scientists tumor immunologists translational investigators GMP manufacturing teams and clinical trial leaders to move engineered T-cell therapies into clinical testing.

• Contribute to building scalable discovery pipelines for antigen identification functional screening and preclinical validation.

• Participate in multidisciplinary team science initiatives across Mayo Clinic campuses.

The successful candidate will help shape an integrated T-cell therapy strategy encompassing CAR-T TCR and TIL platforms strengthening Mayo Clinic Floridas leadership in immune cell therapy innovation.

Research Environment

Mayo Clinic Florida provides a collaborative multidisciplinary academic medical center environment with strategic investment in cancer immunotherapy and cell therapy translation. Faculty benefit from:

• Established CAR-T and immune cell therapy clinical programs

• Growing infrastructure supporting TIL therapy development and clinical implementation

• State-of-the-art cell manufacturing and GMP facilities

• Institutional core resources including genomics single-cell sequencing proteomics bioinformatics and advanced imaging

• Disease-focused research centers supporting oncology and immune-mediated disease programs

• Cross-campus collaboration opportunities with Mayo Clinic in Minnesota and Arizona

• Dedicated support for regulatory strategy IND-enabling studies and early-phase clinical trial development

The selected candidate will join a rapidly expanding ecosystem designed to accelerate discovery-to-clinic translation of engineered T-cell therapies.