Senior Scientist, Translational Science & Diagnostics (TSDx)

Your mission is to apply your scientific expertise to the design execution and analyses of translational data packages derived for assets in our clinical oncology portfolio. Working as a key member of cross-functional teams you will be responsible for developing and analyzing biomarker assay data from multiple modalities (IHC NGS FISH imaging etc.) and contributing directly to the advancement of our novel Bicycle Drug Conjugates (BDCs) and Bicycle Radio Conjugates (BRCs) from discovery into the clinic including companion diagnostics development.

Scientific Strategy & Innovation

• Contribute to the design and execution of translational strategies that align with project goals focusing on the development of robust biomarker packages for patient selection proof-of-mechanism and pharmacodynamic assessment.
• Represent TSDx department on global project teams for nuzefatide (BT5528) and zelenectide (BT8009) to execute prioritized team biomarker strategy.
• Identify and champion opportunities for innovation across biomarker analytical methodologies proposing creative solutions and new approaches to solve scientific challenges.

Project Delivery & Execution

• Independently perform and oversee quantitative analysis of biomarker data sets from clinical studies through management of activities at third party laboratories (e.g. CROs and/or academic collaborators) to ensure delivery of high-quality timely interpretable results.
• Lead authorship of biomarker sections of team technical documents such as clinical protocols investigator brochure lab manual and regulatory briefing books as required. Seek opportunities to contribute to present clinical biomarker data packages via external scientific publications.
• Present scientific findings and their interpretation clearly and effectively at project team meetings and to cross-functional stakeholders.

Qualifications :

• Demonstrated expertise in a biopharmaceutical setting of design delivery analysis and interpretation of clinical biomarker data (e.g. IHC NGS FISH imaging etc.) in oncology clinical trials (solid or liquid tumors).
• Demonstrated capability of delivering clinical biomarker assay development at third party laboratories within the context of a clinical trial. Experience working as biomarker lead within global oncology project teams is highly desirable.
• Familiarity with and experience of the regulatory requirements of conducting clinical biomarker studies up to and including companion diagnostics would be an advantage.
• Advanced degree (MS PhD or equivalent) in a relevant scientific discipline is preferred

Values & Behaviours: 
Knowledge & Expertise

• Core Expertise: You apply strong scientific expertise to confidently design and execute clinical biomarker studies.
• Data / Insight: You independently interpret complex clinical biomarker data identifying patterns drawing conclusions and understanding the implications for the project.
• Knowledge Sharing: You actively build collective expertise by sharing learnings and mentoring more junior colleagues.

Job Complexity

• Task / Project Delivery: You independently deliver work of moderate to high complexity managing multiple responsibilities and contributing to significant project milestones.
• Problem-Solving: You anticipate scientific challenges and develop practical creative solutions when they arise.
• Strategic Impact: You provide key data and scientific insights that directly inform project decisions and shape team priorities.

Independence

• Autonomy: You operate independently in your daily research activities requiring minimal supervision on routine work.
• Decision-Making: You select suitable methods and approaches with sound scientific judgment making informed decisions that influence team success.
• Leadership / Mentorship: You mentor junior colleagues and act as a source of technical expertise sharing best practices and supporting their development.

Additional Information :

• Flexible working environment
• Competitive reward including annual company bonus 
• Medical dental and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company 
• Health and Dependent Care Flexible Spending Accounts 
• 401(k) plan with a 4% Company match and immediate vesting 
• Eligibility to accrue up to 23 paid time off days per full year worked plus the option to buy up to 5 additional days 
• Employee assistance program
• Employee recognition schemes
• 10 Company holidays 
• Competitive Family Leave Policy 
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc. 

Compensation:  

• Salary Range: $126000 - $157000

We have shared the expected recruitment base pay range for this full-time position based on the anticipated location. The actual base pay will depend on several factors unique to each candidate including skills qualifications experience and the actual location of the role. At Bicycle base pay is just one component of the total reward package. This role is also eligible for Bicycles discretionary annual bonus program (or sales incentive program) its comprehensive health and retirement benefit programs and equity grants. During the hiring process your Bicycle recruiter can share more about the Companys total reward package. 

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore all qualified applicants will be considered for employment and we do not discriminate on the basis of race religion color gender sexual orientation age disability status marital status or veteran status.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore all qualified applicants will be considered for employment and we do not discriminate on the basis of race religion colour gender sexual orientation age disability status marital status or veteran status.

Remote Work :

No

Employment Type :

Full-time