Scientist I

The Toxins group within the Product Development Science & Technology (PDS&T) - Biologics organization supports manufacturing process validation regulatory submission and continuous improvement for late-stage and commercial manufacturing of biological toxin products at AbbVie. We have an exciting opportunity for a Scientist I position based in Irvine CA. This role involves leveraging scientific and bioengineering principles to develop bioassays for analytical testing at drug substance and drug product release and stability time points. The candidate must possess in-depth knowledge and hands-on experience in a range of techniques including but not limited to molecular cloning mammalian cell culture PCR Western blot protein expression purification bioassay transfection and laboratory automation platforms. Moreover excellent communication skills and the ability to thrive in a multi-disciplinary and cross-functional team environment are essential for success in this role.

Key responsibilities include:

• Develop program operate and troubleshoot robotic automation platforms including Hamilton STAR liquid handlers and Opentrons to support high-throughput screening and testing.
• Lead scientific initiatives by generating innovative technical ideas and strategic approaches to advance research goals and address experimental challenges.
• Demonstrate strong scientific judgment by aligning research activities with project objectives and adapting experimental plans based on new data evolving priorities and project developments.
• Design execute and interpret complex experiments using rigorous reproducible methodologies. Develop optimize and implement novel experimental protocols by leveraging emerging technologies to advance scientific progress and resolve technical issues.
• Maintain current expertise in relevant scientific and technical disciplines and apply best practices from current literature to experimental design troubleshooting and method development.
• Establish and manage experimental timelines track progress closely and ensure timely delivery of project milestones through strong organization and time-management.
• Draft review and edit SOPs technical reports publications presentations and patent applications in accordance with industry and regulatory standards.
• Communicate scientific concepts experimental data and key findings effectively to cross-functional teams and stakeholders through clear written and oral presentations.

Qualifications :

• Bachelors degree or equivalent education with typically 5 years of relevant experience; or Masters degree or equivalent education with typically 2 years of relevant experience in Cell and Molecular Biology Biochemistry Biochemical or Biomedical Engineering Biotechnology or a closely related discipline.
• Hands-on experience with scripting and programming robotic liquid handlers (e.g. Hamilton STAR and Opentrons) and proficiency in software platforms like VENUS and Python.
• Experience translating manual cell-based assays including ELISA and potency assays into automated workflows.
• Practical experience with molecular cloning mammalian cell culture PCR Western blotting bioassays and transfection procedures.
• Knowledgeable in genome editing approaches including CRISPR/Cas9 with a solid understanding of experimental design execution and validation of gene-editing studies.
• Experience in optimizing and qualifying cell-based potency assays including sample testing.
• Strong computer skills essential for scientific research including word processing spreadsheets presentation software and advanced data analysis. Ability to analyze interpret and present complex datasets using scientific software such as Python R and JMP.
• Previous GxP experience and attention to detail in documentation preferred.
• Demonstrated ability to design experiments solve problems creatively develop comprehensive experimental plans and independently troubleshoot and validate results.
• Ability to stay current with scientific advances critically evaluate relevant literature and rapidly incorporate new concepts and techniques into research activities.
• Detail-oriented with a proven ability to generate high-quality reproducible data within tight deadlines.
• Strong interpersonal and collaboration skills with the ability to work effectively in multidisciplinary cross-functional teams and communicate complex scientific concepts clearly in both verbal and written formats.
• Self-motivated adaptable and committed to scientific discovery continuous learning and process improvement.
• Experience developing and optimizing these models for research or drug discovery applications is highly desirable.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our short-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of  any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only - to learn more visit  & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:

Work :

No

Employment Type :

Full-time