Senior Scientist, Translational Science & Diagnostics (TSDx)

Your mission is to apply your scientific expertise to the design execution and analyses of translational data packages derived for assets in our clinical oncology portfolio. Working as a key member of cross-functional teams you will be responsible for developing and analyzing biomarker assay data from multiple modalities (IHC NGS FISH imaging etc.) and contributing directly to the advancement of our novel Bicycle Drug Conjugates (BDCs) and Bicycle Radio Conjugates (BRCs) from discovery into the clinic including companion diagnostics development.

Scientific Strategy & Innovation

• Contribute to the design and execution of translational strategies that align with project goals focusing on the development of robust biomarker packages for patient selection proof-of-mechanism and pharmacodynamic assessment.
• Represent TSDx department on global project teams for nuzefatide (BT5528) and zelenectide (BT8009) to execute prioritized team biomarker strategy.
• Identify and champion opportunities for innovation across biomarker analytical methodologies proposing creative solutions and new approaches to solve scientific challenges.

Project Delivery & Execution

• Independently perform and oversee quantitative analysis of biomarker data sets from clinical studies through management of activities at third party laboratories (e.g. CROs and/or academic collaborators) to ensure delivery of high-quality timely interpretable results.
• Lead authorship of biomarker sections of team technical documents such as clinical protocols investigator brochure lab manual and regulatory briefing books as required. Seek opportunities to contribute to present clinical biomarker data packages via external scientific publications.
• Present scientific findings and their interpretation clearly and effectively at project team meetings and to cross-functional stakeholders.

Qualifications :

• Demonstrated expertise in a biopharmaceutical setting of design delivery analysis and interpretation of clinical biomarker data (e.g. IHC NGS FISH imaging etc.) in oncology clinical trials (solid or liquid tumors).
• Demonstrated capability of delivering clinical biomarker assay development at third party laboratories within the context of a clinical trial. Experience working as biomarker lead within global oncology project teams is highly desirable.
• Familiarity with and experience of the regulatory requirements of conducting clinical biomarker studies up to and including companion diagnostics would be an advantage.
• Advanced degree (MS PhD or equivalent) in a relevant scientific discipline is preferred

Values & Behaviours: 
Knowledge & Expertise

• Core Expertise: You apply strong scientific expertise to confidently design and execute clinical biomarker studies.
• Data / Insight: You independently interpret complex clinical biomarker data identifying patterns drawing conclusions and understanding the implications for the project.
• Knowledge Sharing: You actively build collective expertise by sharing learnings and mentoring more junior colleagues.

Job Complexity

• Task / Project Delivery: You independently deliver work of moderate to high complexity managing multiple responsibilities and contributing to significant project milestones.
• Problem-Solving: You anticipate scientific challenges and develop practical creative solutions when they arise.
• Strategic Impact: You provide key data and scientific insights that directly inform project decisions and shape team priorities.

Independence

• Autonomy: You operate independently in your daily research activities requiring minimal supervision on routine work.
• Decision-Making: You select suitable methods and approaches with sound scientific judgment making informed decisions that influence team success.
• Leadership / Mentorship: You mentor junior colleagues and act as a source of technical expertise sharing best practices and supporting their development.

Additional Information :

• State-of-the-art campus environment with on campus restaurant and Montessori nursery
• Flexible working environment
• Competitive reward including annual company bonus 
• Employee recognition schemes
• 28 days annual leave in addition to bank holidays  option to buy up to 5 additional days annually
• Employer contribution to pension (employee does not have to contribute) 
• Life assurance cover 4x basic salary 
• Private Medical Insurance including optical and dental cover 
• Enhanced parental leave policies
• Group income protection
• Employee assistance program
• Health Cash Plan
• Access to company subsidized gym membership
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc. 
• Cycle to work scheme 

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore all qualified applicants will be considered for employment and we do not discriminate on the basis of race religion colour gender sexual orientation age disability status marital status or veteran status.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore all qualified applicants will be considered for employment and we do not discriminate on the basis of race religion colour gender sexual orientation age disability status marital status or veteran status.

Remote Work :

No

Employment Type :

Full-time